People

Dr. Smitha V. B.

Associate Professor

Department of Biotechnology

University of Calicut

Calicut University PO 673 635

Kerala - India

Phone (Off): 0494 2407403, 4

Residence Address:

Chitra Gardens

Pangappara PO

Thiruvananthapuram-695581

Mobile no: +91 8139866731

(Res): 0494-2401972

Email:This email address is being protected from spambots. You need JavaScript enabled to view it.

Educational Qualifications

Awarded Ph.D. from Kerala University, TVM on March 2008

2002-2007 Ph.D. in Biotechnology, Rajiv Gandhi Centre for Biotechnology, TVM

1999 - 2001 - M.Sc. Biotechnology - Cochin University of Science and Technology

1996 - 1999 - B.Sc. Zoology - Maharajas College Ernakulum, Mahatma Gandhi University

1993-1995- Predegree Science- Sacred Hearts College, Kochi

1993- SSLC- St. Teresas Higher Secondary School, Kochi

Specialization: Molecular Oncology

H Index: 11(Scopus)

Awards and Scholarships

Post-Doctoral Fellow mentorship by Kerlala Higher Education Council Chief Minister's Nava Kerala mission PDF Programme (2022)
“Peraringnar Anna Award” from Madurai Kamaraj University for the best research paper published in international journals in the field of Cancer Biology for the year 2005
CSIR Research Fellowship (Dec 2001) and NET (July 2001)

Awards: Ph.D. Students

Remya Johny:

1.Best poster award at National conference on Phytomedicine , conducted by Bharatiyar University, TN, India (5^th – 6^th January 2023).

2.Best Paper award at the 37th Kerala Science Congress held at Kerala Agricultural University, Thrissur during 7-10 February 2025.

Meghna Sudhesh :

Best Paper Presentation Award at INSIGHT 2025: International Conference on Integrating Disciplines for Sustainable Development, organized by MES Keveeyam College, Valanchery, in association with the Kerala State Higher Education Council, on January 21-23, 2025.

Amrutha Nisthul A:

1. Best Poster Award at 36th Kerala Science Congress, February 2024 at Government College, Kasaragod.

2. Best Paper Presentation Award at National Conference-Exploring Synergies: Insights in Life Science and Structural Biology (ESILS - 2024), April 2024,organized by Department of Biotechnology and Microbiology, Kannur University.

Aiswarya US: Best poster award at 30th Kerala Science Congress 69-70 (2018 Jan)

Research Projects

Funding Agency: KSCSTE; Grant: Thirty Lakhs

Title: Isolation, identification and characterization of anticancer principle from the medicinal plant, Corallocarpus epigaeus

Publications: Peer-Reviewed International Journals

Faisal Moossa Athikkavil, Aiswarya U S, Remya Johny, Meghna Sudhesh, Amrutha Nisthul, Ravi Shankar Lankalapalli, Ruby John Anto and Smitha V B., A potent bioactive fraction against colon cancer from Plectranthus vettiveroides; Exploration of Targeted Anti-tumor Therapy (2023), 4, 227-239. DOI: https://doi.org/10.37349/etat.2023.00131
Anwar Shabna, Jayesh Antony, Vinod Vijayakurup, Minakshi Saikia, Vijayasteltar BLiju, Archana P Retnakumari, Nisthul A Amrutha, Vijai V Alex, Mundanattu Swetha,Sreekumar U Aiswarya, Somaraj Jannet, Uma Subramanian Unni, Sankar Sundaram, Daisy R Sherin, Nikhil Ponnoor Anto, Smitha V Bava, Sadasivan Chittalakkottu, Sophia Ran, and Ruby John Anto (2022). Pharmacological attenuation of melanoma by tryptanthrin pertains to the suppression of MITF-M through MEK/ERK signaling axis. Cellular and Molecular Life Sciences, 79(9), 1-19. (IF- 9.261)
Aiswarya US, GVikas , NHHaritha , VBLiju , A Shabna , MSwetha , T P Rayginia , C KKeerthana , Lekshmi RNath , MVReshma , SSundaram , Nikhil PA, Ravi SL, Ruby JA, Smitha VB; Cucurbitacin B, Purified and Characterized From the Rhizome of Corallocarpus epigaeus Exhibits Anti-Melanoma Potential; Frontiers in Oncology;2022 Jun 8;12:903832;DOI: 10.3389/fonc2022.903832; (IF-5.738).
Ruby John Anto, Haritha Hariprasad Nair, Akbar Nawab, Vinod Vijayakurup, Nikhil Ponnoor Anto, Vijayasteltar B Liju, Vijai V Alex, Amrutha Nisthul A, Aiswarya U S, Swetha Mundanattu, Balachandran S Vinod, Sankar Sundaram, Maria V Guijarro, Thomas Herlevich, Nesteena K N, Smitha V B, Sadasivan Chittalakkottu, Maria Zajac-Kaye: Targeting thymidylate synthase enhances the chemosensitivity of triple-negative breast cancer towards 5-FU-based combinatorial therapy: Frontiers in Oncology Front Oncol. 2021 Jul 15;11:656804. doi: 10.3389/fonc.2021.656804, (IF – 5.738)
Isha Godwin, Nikhil Ponnoor Anto, Smitha V Bava, Mani Shankar Babu, Goodwin G Jinesh; Targeting K-Ras and apoptosis-driven cellular transformation in cancer; Cell death discovery; No.7/1, Apr 14, 2021,(IF – 7.109).
Mohan Shankar G.1,, Vijai V. Alex, Amrutha Nisthul A., Smitha V. Bava, Sankar Sundaram, Archana P. Retnakumari, Sadasivan Chittalakkottu and Ruby John Anto; Pre‐clinical evidences for the efficacy of tryptanthrin as a potent suppressor of skin cancer; Cell Proliferation; Oct 30-2019, (IF – 8.755)
Bava, Smitha V., Arun Kumar T. Thulasidasan, Chanickal N. Sreekanth, and Ruby John Anto. "Cervical cancer: A comprehensive approach towards extermination." Annals of medicine; 48, no. 3 (2016): 149-161. (IF – 5.348)
Puliyappadamba, Vineshkumar T., Arun Kumar T. Thulasidasan, Vinod Vijayakurup, Jayesh Antony, Smitha V. Bava, Shabna Anwar, Sankar Sundaram, and Ruby John Anto. "Curcumin inhibits B [a] PDE‐induced procarcinogenic signals in lung cancer cells, and curbs B [a] P‐induced mutagenesis and lung carcinogenesis." BioFactors; 41, no. 6 (2015): 431-442. (IF - 6.438)
Radhakrishnan, E. K., Smitha V. Bava, Sai Shyam Narayanan, Lekshmi R. Nath, Arun Kumar T. Thulasidasan, Eppurathu Vasudevan Soniya, and Ruby John Anto. "[6]-Gingerol induces caspase-dependent apoptosis and prevents PMA-induced proliferation in colon cancer cells by inhibiting MAPK/AP-1 signaling." PLoS One; 9, no. 8 (2014): e104401. (IF - 3.752)
Sreekanth, C. N., S. V. Bava, E. Sreekumar, and R. J. Anto. "Molecular evidences for the chemosensitizing efficacy of liposomal curcumin in paclitaxel chemotherapy in mouse models of cervical cancer." Oncogene; 30, no. 28 (2011): 3139. (IF – 8.756)
Bava, Smitha V., Chanickal N. Sreekanth, Arun Kumar T. Thulasidasan, Nikhil P. Anto, Vino T. Cheriyan, Vineshkumar T. Puliyappadamba, Sajna G. Menon, Santhosh D. Ravichandran, and Ruby John Anto. "Akt is upstream and MAPKs are downstream of NF-κB in paclitaxel-induced survival signaling events, which are down-regulated by curcumin contributing to their synergism." International journal of biochemistry & cell biology; 43, no. 3 (2011): 331-341. (IF - 5.652)
Puliyappadamba, Vineshkumar T., Vino T. Cheriyan, Arun Kumar T. Thulasidasan, Smitha V. Bava, Balachandran S. Vinod, Priya R. Prabhu, Ranji Varghese, Arathy Bevin, Shalini Venugopal, and Ruby John Anto. "Nicotine-induced survival signaling in lung cancer cells is dependent on their p53 status while its down-regulation by curcumin is independent." Molecular cancer; 9, no. 1 (2010): 220. (IF- 41.444)
Laladhas, Krishna P., Vino T. Cheriyan, Vineshkumar T. Puliappadamba, Smitha V. Bava, Rajesh G. Unnithan, Parvathy L. Vijayammal, and Ruby John Anto. "A novel protein fraction from Sesbania grandiflora shows potential anticancer and chemopreventive efficacy, in vitro and in vivo." Journal of cellular and molecular medicine; 14, no. 3 (2010): 636-646. (IF - 5.295)
Bava, Smitha V., Vineshkumar T. Puliappadamba, Ayswaria Deepti, Asha Nair, Devarajan Karunagaran, and Ruby John Anto. "Sensitization of taxol-induced apoptosis by curcumin involves down-regulation of nuclear factor-κB and the serine/threonine kinase Akt and is independent of tubulin polymerization". Journal of Biological Chemistry; 280, no. 8 (2005): 6301-6308. (IF - 5.486).

Publications: Non-Peered Reviewed

Remya Johny, Faisal Moossa Athikkavil, Aiswarya U S, Ruby John Anto, Smitha VB.,’ Evaluation of the chemotherapeutic potential of a column fraction isolated from Sphagneticola trilobata against Colon cancer, in vitro. (International conference on Advance Research- INSIGHT) February 2024, Page No: BOT 2 conducted by MES Kaveeyam College Valachery.
Meghna Sudhesh,Aishwarya U.S,Remya Johny, Faisal Moossa Athikkavil,Ruby John Anto, Smitha VB.'Anti-melanoma efficacy of Corallocarpus epigaeus tuber',(International conference on Advance Research- INSIGHT) February 2024,conducted by MES Kaveeyam College Valachery.
Faisal Moossa Athikkavil, Aiswarya U S, Remya Johny, Meghna Sudhesh, Ruby John Anto and Smitha V B., “PVF, a bioactive fraction from Plectranthus vettiveroides potentiates apoptosis in colon cancer cells” (International conference on Molecular Medicine and Therapeutics) January 2023, Page No: 65 conducted by Annamalai University, TN.
Remya Johny, Faisal Moossa Athikkavil, Aiswarya U S, Ruby John Anto and Smitha V B., “Evaluation of anticancer potential of bioactive fraction (ESF) from Sphagneticola trilobata against colon cancer cell. (International conference on Molecular Medicine and Therapeutics) January 2023, Page No: 58 conducted by Annamalai University, TN.
Meghna Sudhesh, Aiswarya U S, Faisal Moossa Athikkavil, Remya Johny, Amrutha A, Ruby John Anto and Smitha V B., “Methanol extract of Corallocarpus epigaeus tuber exhibits antimelanoma potential” (International conference on Molecular Medicine and Therapeutics) January 2023, Page No: 58 conducted by Annamalai University, TN.
Faisal Moossa Athikkavil, Aiswarya U S, Remya Johny, Meghna Sudhesh, Ruby John Anto and Smitha V B ., PVF, a purified column fraction from the medicinal plant, Plectranthus vettiveroides (Jacob) N. P Singh & B. D. Sharma is highly efficacious against colon cancer. (National conference on Phytomedicine – Medicinal plants, International journal of phytomedicine and related industries) January 2023, Page No: 15 conducted by Bharatiyar University, TN, India Print ISSN:0975-4261, Online ISSN:0975-6892.
Remya Johny, Faisal Moossa Athikkavil ,Aiswarya U S ,Ruby John Anto and Smitha V B., “A bioactive fraction (ESF), isolated from Sphagneticola trilobata(L.) Pruski exhibits anticancer potential against colon cancer cells” (National conference on Phytomedicine – Medicinal plants, International journal of phytomedicine and related industries) January 2023, Page No: 101 conducted by Bharatiyar University, TN, India Print ISSN:0975-4261, Online ISSN:0975-6892.
Meghna Sudhesh, Aiswarya U S, Faisal Moossa Athikkavil, Remya Johny, Amrutha A, Ruby John Anto and Smitha V B., “Anti-melanoma efficacy of the methanol extract of Corallocarpus epigaeus(Rottler) Hook.f. tuber” (National conference on Phytomedicine – Medicinal plants, International journal of phytomedicine and related industries) January 2023, Page No: 60 conducted by Bharatiyar University, TN, India Print ISSN:0975-4261, Online ISSN:0975-6892. .
Meghna Sudhesh, Aiswarya U S, Faisal Moossa Athikkavil, Remya Johny, Amrutha A, Ruby John Anto and Smitha V B., “Evaluation of anti-proliferative potential of the methanol extract of Corallocarpus epigaeus tuber” (Multi-disciplinary online international conference- Quaesitio 2022-23) December 2022, conducted by St. Stephens college, Uzhavoor, Kerala
Amrutha Nisthul A, Aiswarya U S, Meghna Sudhesh, Ruby John Anto, C Sadasivan and Smitha V B ., “In silico studies exploring the possibility of Cucurbitacin B as an MEK inhibitor in the treatment of melanoma” (International conference on drug discovery) November 2022, conducted by Schrodinger and BITS Pilani, Goa
Meghna Sudhesh, Aiswarya U S, Faisal Moossa Athikkavil, Remya Johny, Amrutha A, Ruby John Anto and Smitha V B., "Anti-melanoma potential exhibited by tuber of Corallocarpus epigaeus”. (National seminar entitled Current Trends In Medical Biotechnology: an interdisciplinary approaches for healthy life) November 2022, conducted by Government Degree College (Men) - Srikakulam & Society for Biotechnologists
Faisal Moossa Athikkavil, Remya Johny, Aiswarya U S ,Ruby John Anto and Smitha V B ., In vitro Evaluation of the Anticancer Property of the Aromatic Medicinal Plant Plectranthus vettiveroides.(International Virtual Conference on Evolving Paradigms in Biotechnology: Combating Contemporary Challenges) April 1 & 2, 2022, Page No: 18 conducted by Kristu Jayanti College, Bengaluru, Karnataka, India ISBN:978-81-956813-0-3.
Remya Johny, Faisal Moossa Athikkavil ,Aiswarya U S ,Ruby John Anto and Smitha V B ., Sphagneticola trilobata Leaf Extract Induces Apoptosis in the Colon Cancer Cell Line HCT116. (International Virtual Conference on Evolving Paradigms in Biotechnology: Combating Contemporary Challenges) April 1 & 2, 2022, Page No: 18 conducted by Kristu Jayanti College, Bengaluru, Karnataka, India ISBN: 978-81-956813-0-3
Aiswarya U S, Haritha H Nair, Jaice Ravindran, Ravi Shankar Lankalapalli, Ruby John Anto, Smitha V B, Isolation identification and characterization of potent anticancer compounds from the medicinal plant Corallocarpus epigaeus effective against malignant melanoma, International Webinar on Phytochemistry- Impacts and Applications Organized by Kerala Academy of Science, September 11, 2021.
Faisal Moossa Athikkavil, Remya Johny, Aiswarya U.S., Ruby John Anto & Smitha V.B. Anticancer potential of an aromatic medicinal plant Plectranthus vettiveroides. The International conference on agriculture, climate change & Life Sciences 2021), 05 March 2021, ISBN: 978-93-90146-15-4 Organized by International Multidisciplinary Research Foundation, India.
Aiswarya U S, Haritha H Nair, Vikas G, Ravi Shankar Lankalapalli, Ruby John Anto, Smitha V B, Isolation identification and characterization of potent anticancer compounds from the medicinal plant Corallocarpus epigaeus effective against melanoma, 33^rd Kerala Science Congress, January 2021
Aiswarya U S, Haritha H Nair, Vikas G, Ravi Shankar Lankalapalli, Ruby John Anto, Smitha V B, Isolation and identification of potent anticancer compounds from the plant, Corallocarpus epigaeus, 32^nd Kerala Science Congress, January 2020
Faisal Moossa Athikkavil, Remya Johny, Ruby John Anto & V.B. Smitha., Cytotoxic activity of an endemic South Indian aromatic medicinal plant Plectranthus vettiveroides. XLII All India Botanical Conference & National Symposium on "Innovations and Inventions in Plant Science Research November 6-8, 2019, Page No: 221-222.
Aiswarya U S, Haritha H Nair, Jaice Ravindran, Ravi Shankar Lankalapalli, Ruby John Anto, Smitha V B. Evaluation of the Medicinal Plant Corallocarpus epigaeus for Anti-Cancer Property, 8^th Annual meeting of Indian Academy of Biomedical Sciences & conference on Deliberation on Translation of Basic Scientific Insights into Affordable Health Care Products February 25-27,2019, Page No. 174-175, CSIR- NIIST, Thiruvananthapuram.
Aiswarya U S, Haritha H Nair, Jaice Ravindran, Ravi Shankar Lankalapalli, Ruby John Anto, Smitha V B. Corallocarpus epigaeus: A Potent Medicinal Plant with Anti-Cancer Property, State Level Seminar on Biotechnology for “Biodiversity Conservation and Utilization” November 2, 2018, Page No. 24-25, Sree Narayana College of Technology, Kollam.
Aiswarya U S, Haritha H Nair, Jaice Ravindran, Ravi Shankar Lankalapalli, Ruby John Anto and Smitha V B. Tubers of the Medicinal Plant Corallocarpus epigaeus Possess Potent Anti-Cancer Principles Effective against Hepatocellular Carcinoma, 3 rd International Conference on “Nutraceuticals and Chronic Diseases” September14-16, 2018, Rishikesh-Dehradun, India.
Smitha V B and Aiswarya U S. Bioprospecting a Strategy for Discovering Chemotherapeutic Agents for Cancer, National Seminar on New Horizons in Cancer Treatment and Prevention: From Bench to Bedside, March 2018, ISBN 978-93-5300-765-2, Page No. 27.
Aiswarya U S, Haritha H Nair, Ravi Shankar L, Ruby John Anto, Smitha V B. A Bioactive Fraction from the Medicinal Plant Corallocarpus epigaeus Induces Apoptosis in Hepato-Carcinoma cells; National Seminar on New Horizons in Cancer Treatment and Prevention: From Bench to Bedside, March 2018, Sree Narayana College, Kollam, ISBN 978-93-5300-765-2
Aiswarya U S, Haritha H Nair, Ravi Shankar L, Ruby John Anto, Smitha V B. FFC, A potent Fraction from the Medicinal Plant Corallocarpus epigaeus induces cytotoxicity in hepatocellular carcinoma via Induction of Apoptosis. Proceedings of 7th ICTCR 2018 page 78.
Aiswarya U.S., Haritha H. Nair, Ruby John Anto and Smitha V.B. A study on the anticancer potential of the medicinal plant Corallocarpus epigaeus. Proceedings of 30th Kerala Science Congress 69-70 (2018 Jan.)
Remya Johny, Aiswarya U.S., Smitha V.B. Ruby John Anto scientific analysis of the bioactive properties of mistletoe Dendrophthoe falcata, growing on the spice plant Myristica fragrans Proceedings of 30th Kerala Science Congress 71-72 (2018 Jan.)
Lakshmi RN, Sophia MJ, Nikhil PA,Sai SN, Smitha VB and Ruby JA. “4-O-Methylgallic acid, isolated from the leaves of the mistletoe growing on Saraca asoca induces caspase-mediated apoptosis in cervical cancer cells via down-regulation of HPV” 343rd OMICS International Conference, Journal of Biotechnology & Biomaterials, August 2015 Volume 5, Issue 2, ISSN: 2155-952X, Proceedings of 8th Euro Biotechnology Congress August 18-20, 2015 Germany.
CN Sreekanth, Smitha VB, Arun Kumar TT, N P Anto, VT Cheriyan, Vineshkumar TP, SG Menon, SD Ravichandran and *Ruby John Anto. Curcumin: A Potent Candidate to be Evaluated as a Chemosensitizer in Paclitaxel Chemotherapy Against Cervical Cancer. In: Perspectives in Cancer Prevention-Translational Cancer Research. P editors-Sudhakaran P, Oommen V, Pillai, MR (Eds.). Pubd: Springer; 2014 edition (October 25, 2013)
Chanickal. N. Sreekanth, Smitha. V. Bava and Ruby John Anto. Curcumin: A potent candidate to be evaluated as a chemosensitizer in paclitaxel chemotherapy against cervical cancer., Fourth International Conference on Translational Cancer Research: Recent Developments in Cancer Prevention, Udaipur, Rajasthan, India, December 16th-19th, 2011.
Chanickal. N. Sreekanth, Smitha. V. Bava and Ruby John Anto. Chemosensitizing efficacy of curcumin in paclitaxel chemotherapy as evidenced by chemical-induced and xenograft models of cervical cancer, 3rd International Conference on Drug Discovery & Therapy-Feb 7 - 10, 2011, Dubai.
Ruby John Anto, Smitha V.B., Vinesh Kumar T.P., Sreekanth C.N., Vinod B.S., Vino T. Cherian, Priya R Prabhu and Gayathri L.T., p-202-208, Phenolics of the functional food – “Curcumin- A nutraceuticals with potential chemosensitive property”, Role of dietary fibers and nutraceuticals in preventing diseases, Pubd -Pharma Med Press, 2007.
Vineshkumar.TP, Smitha Bava and Ruby John Anto (2005) Curcumin down-regulates Nicotine resistance in lung cancer cells Indian Journal of Medical Research. (supplement), 100
“Sensitization of taxol-induced apoptosis by curcumin involves down regulation of NF-B and Akt and is independent of tubulin polymerization” at Apoptosis 2005 (International Symposium on Translational Research) held at Trivandrum, December 2005.
Smitha Bava, Vineshkumar T.P and Ruby John Anto. Molecular mechanism behind the synergistic effect of taxol and curcumin.; Proceedings of 17th Kerala Science Congress 75-77, Jan 2005.
Smitha VB and Ruby John Anto. Anti-apoptotic proteins as targets of chemotherapy. Amala Research Bullettin, 2004, 23, 1-6.
“Down-regulation of NF-κB by curcumin sensitizes HeLa cells to taxol induced apoptosis” at International Workshop on Cervical Cancer held at NCBS Bangalore, November 2004.
Ruby John Anto, Karunagaran D and Smitha VB. Curcumin potentiates taxol induced apoptosis of cervical cancer cells. Proceedings of Kerala Science Congress, 2003, 15, 263- 268

Chapters in Text Books

Cucurbitacin B: A Potential Therapeutic Agent Against Liver Cancer by A Amrutha Nisthul, US Aiswarya, MA Faisal and VB Smitha.,Liver Cancer and Phytomedicine(March 2025) World Scientific connect.
Kalishwaralal, Kalimuthu, Ajmani Abhishek, Chenicheri K. Keerthana, Tennyson P. Rayginia, Mundanattu Swetha, Sreekumar U. Aiswarya, Jaison Arivalagan, Smitha V. Bava, Michael A. Firer, and Ruby John Anto (2023). Selenium Metabolic Pathway in Ferroptotic Cell Death. In Ferroptosis in Health and Disease (pp. 369-382). Cham: Springer International Publishing.
Aiswarya, S. U. D., & Smitha V.B., (2023). Unveiling the Potency of Phyto-Constituents to Target TNBC: Mechanism to Therapeutics. Therapeutic Drug Targets and Phytomedicine For Triple Negative Breast Cancer, 145.
CN Sreekanth, Smitha V.B., Arun Kumar TT, N P Anto, VT Cheriyan, Vineshkumar TP, SG Menon, SD Ravichandran and Ruby John Anto - Curcumin: A Potent Candidate to be Evaluated as a Chemosensitizer in Paclitaxel Chemotherapy Against Cervical Cancer. In: Perspectives in Cancer Prevention-Translational Cancer Research. P editors-Sudhakaran P, Oommen V, Pillai, MR (Eds.). Pubd: Springer; 2014 edition (October 25, 2013) Molecular Biology of Cancer
Ruby John Anto, Smitha V.B., Vinesh Kumar T.P., Sreekanth C.N., Vinod B.S., Vino T. Cherian, Priya R Prabhu and Gayathri L.T., p-202-208, Phenolics of the functional food – “Curcumin- A nutraceuticals with potential chemosensitive property”, Role of dietary fibers and nutraceuticals in preventing diseases, Pubd -Pharma Med Press, 2007.
Role of Plant-Derived Extracellular Nanovesicles in Triggering Innate Immune Response Against Plant Pathogens
ByVandana Sharma, Victor Samuel, Chenicheri K Keerthana, Praveen Archana, Shifana Chembothumparambil Sadiq, Mundanattu Swetha, Tennyson Prakash Rayginia, Sreekumar Usha Devi Aiswarya, Smitha Vadakkeveettil Bava, Manikandan Mohan, Johnson Retnaraj Samuel Selvan Christyraj, Jaison Arivalagan, Sam Aldrin Chandran, Kalimuthu Kalishwaralal (2024),Nanotechnology in Plant Health,CRC Press

Research Guidance

Ph.D.[Ongoing] : 2

Ph.D [Submitted] : 1

PDF[Completed] : 1

Ph.D. [Awarded] :2

Ph.D. Alumini : Faisal Moosa Athikkavil- PDF ,University of Pavia ,Italy

Aiswarya US - PDF, NIIST, Thiruvananthapuram

Membership in University Academic Bodies

Member: Board of Studies-Biotechnology, University of Calicut

Invited Lectures

Talk titled “Women in Science Conclave-We IGNITE-2025” organized by the Kerala State Council for Science,Technology and Environment (KSCSTE),March 15 2025,at Sasthra Bhavan,Pattom,Thiruvananthapuram.
Talk titled “Molecular biology of cancer “at Academic staff College, University of Calicut, September 23rd, 2021 sponsored by UGC/National
Talk titled “Cancer therapeutics and preventives from Nature at Academic staff College, University of Calicut, October 25^th, 2018 sponsored by UGC/National
Talk titled” Bioprospecting for chemotherapeutic agents for Cancer” at National Seminar "New horizons in Cancer Treatment and Prevention: From Bench to Bedside” organized by the Department of Chemistry and Biochemistry, Sree Narayana College, Kollam, jointly sponsored by DST and KSCSTE, on 16th and 17th March 2018
Talk titled “Cancer chemotherapeutic agents from Nature” at The National Seminar on “New Avenues in Bioscience Research conducted at School of Biosciences, M.G. University, in association with DST and PURSE 2 on 19 and 20th March, 2018
Talk Titled “Bioprospecting for Cancer Chemotherapeutic agents from plants” at National Seminar on Phytochemistry and Pharmacognosy organized by Directorate of Collegiate Education, Govt. of Kerala at Govt. College for Women, Trivandrum on November 4th and 5th, 2017
Talk titled Cancer prevention: A case study approach with Cervical Cancer” at National Seminar titled New trends in Biotechnology Conducted at St. Joseph’s College, Thrissur on Jand 5th and 6th, 2016
Talk titled Cancer: “Through the lens of Molecular Biology”, February, 2015 ., on World cancer day, at Audio Visual Theater of Farook college, Calicut

Participations: Chaired Person in Seminar/Conferences

Chairperson for Oral presentation Sessions at the International Conference on Molecular Biology : An underpinning of Life Science conducted by the Dept. of Zoology, Farrok College; Kozhikode, for two days [January 8-9,2018, sponsored by UGC]/International.

Memberships/Professional affiliations:

Member, Society for Biotechnologists, India

Member, Indian Association of Cancer Research

Member, Society for Neutraceuticals and Chronic Diseases

gopi sir Sri. Gopinathan C

Dr. Gopinathan C ,Assosiate Professor Residence Address: 38/612 C, Navami,

Department of Biotechnology AthanikkalWest Hill P.O

University of Calicut Calicut-Kerala.

Calicut University PO

Malappuram - 673 634

Kerala - India

Mobile No : +91 9446252722

Phone (Off) : 0494-2407403

(Res) : 0495-2382722

Email Id : This email address is being protected from spambots. You need JavaScript enabled to view it.

Qualifications.

Degree	University/ Institution	Year
Ph.D Biotechnology	University of Calicut, Department of Biotechnology	2021
M.Tech Biotechnology	Anna University of Science and Technology, Centre for Biotechnology, Chennai	1995
M.Sc Lifesciences (Specilization Microbiology)	University of Calicut, Department of Lifesciences.	1993
B.Sc Botany	NSS College Ottappalam, University of Calicut	1990

Patents

First patent in the University of calicut-Patent number 281240 (Applicationnumber:1266/CHE/2010) titled Fed- batch fermentation technique for the enhanced production of delta endotoxin of Bacillus thuringiensis subspecies isrelensis granted on 10/3/2017 effective from 2010 onwards.
Second Patent Application Complete Specification Filed – title “Penicillin Production Using Solid State Fermentation Technique” (app. No.: TEMP/E-1/5362/2018-CHE, /Ref.No.: 201841005087.
Third patent application complete specification filed – titled – Fixed volume Fed batch fermentaion technique for enhanced production of delta-endotoxin of Bacillus thuringeinsis subspecies israelensis using pre-treated molasses. (App- No. TEMP/E- 1/7741/2020-CHE, Ref. No. 202041007261.

Consultancy

Sl No	Project Details
1	*Implemented a bioags project (bioreactor of volume 5000 litres at Athafi villas, Vellikulangara , Vatakara to treat food wastes in 2008.
2	Invited and attended a meeting on solid waste management as per the invitation of secretary, Tellicherry Muncipality( Ref: H/14575/06, dated 14/7/2006.)
3	Conducted discussions regarding solid waste management using biotechnological methods on 13/12/2006 at Tellicherry Muncipality
4	Participated on behalf of University of Calicut in the meeting on the subject -Solid waste eradication- as an expert as per the request ofSecretary, secretariat of the Kerala Legislatur ( Ref; No:Ad.A4/14071/2001/Misc , dated: 7/12/2007.
5	Installed an anerobic bioreactor with a scale up volume of 50,000 litres at the Rani public school, Vadakara, chorode in 2005, for the large scale production of biogas and electricity from kitchen/ organic wastes using high rate biomethanation technology.
6	Provide technical know how for the implementation of industrial biotechnology projects regarding commercial production of oyster mushrroms, spirulina, and biogas production, at the E.M.E.A college of arts and science, Kondotty , Kumminiparamba, Malappuram district.
7.	Invited for discussion regarding production of drinking water using food and human wastes besides railway tracks/plat forms on 13/11/2015.
8	Installed waste water separator at the S. R. Mills Vadakara, Kerala on 8/4/2015.
9	Provided technical know how for the cost effective process development for the large scale production of lignase and cellulose enxyme and also for technology development related to two phase anaerobic digestion of poultry slaughter house wastes to UWIn life sciences, 6 th cross, 38 th main, Banashankari - 3 rd stage, Bengaluru. (Dated 2/3/2015).
10	Member of the consultancy cell committee as per order no. PlD/IQAC/Con.cell/10, dated 27/11/2010
11	Delivered a talk on the topic solid waste management and rainy seasonal diseases on the inaugural function of Desa koodu residential association, Edakkad, Kozhikode, on June, 26 th , 2016.
12	Held discussions regarding technical feasibility of installing anaerobic reactors/biogas plants for treating food and human waste from railway tracks in order to generate drinking water/steam for cleaning railway coaches, as part of extension work at the office of chief planning and development engineer, Southern Railway, Chennai on 2/2/2016.
13	Provided technology support for an anaerobic biogas plant near university canteen in 2018 for the production of biogas and organic fertilizer.
14	Member of the technical committee constituted by the university for integrated waste management system as per U.O. No: 500/2019/admn. Dated 4/4/2019.
15	Has held discussions with Tirur municipality regarding supply of vegetables and fruit wastes for the upcoming bioenergy plant at the Calicut university campus (Ref: Letter no. H3- 18618/20, date: 2/12/2020.
16	Held technical discussions regarding solid waste management in corporation of calicut as consultant on 2/2/2020
17	Has attended a meeting in the chamber of mayor to discuss the restarting of biogas plants in the central market and Tagore hall, on29/09/21 (Ref. EG 12/10477/19, dated 20/09/21)
18	Invited and has participated in the meetingheld at mayors chamber at 2.30 pm on29/09/21 in order to discuss the renovation andrestarting of biogas plants in central fish market and Tagore hall, Kozhikodecorporation (Ref: no; EG 12/10477/19, dated 20/09/21).
19	Invited as consultant for waste management at Mahatma Ghandhi University, Kottayam on 8/11/2021 and 9/11/2021 by the Hon. Vice Chancellor (Ref. Order No.. 5949/Ad B1/2021/MGU dated 9/11/2021
`20	Appointed as consultant for Kozhikode corporation (Ref. No. EG12/10477/19, dated 28/3/2021) in order to restart the non-functional biogas plants in the central market and Tagore hall.
21	Has implemented roof water harvesting system in administrative block. Connected news paper reports attached.
22	Technical consultant for bioenergy project using fishery wastes in Vadakkara Muncipality

Research Guidance:

M.Sc Projects : 35

M.Phil Projects: 2

Research Publication

Sl No	Title	Journal	ISSN/Year
1	Enhanced production of Bacillus thuringiensis serovar. Israelensis by Fed-batch fermentation	IQSR journal of environmental science, toxicology and food processing	e-ISSN 2319-2402., p-ISSN: 2319-2399, volume 9, issue 4, ver III, April, 2015, pp 14-19.
2	Cost effective pretreatment of cassava peels for enhanced biogas production	IQSR journal of Environmental science, Toxicology and food processing	e-ISSN 2319-2402., p-ISSN: 2319-2399, volume 9, issue 9, ver II, Sep, 2015, pp 21-25.
3	Supplementing pine apple pulp waste with urea and metal ions enhances biogas production	IQSR journal of Environmental science, Toxicology and food processing	e-ISSN 2319-2402., p-ISSN: 2319-2399, Volume 9, issue 10, ver I, Oct, 2015, pp 53-57.
4	Reduction of sporulation time by solid state fementation of Bacillus thuringiensis subspecies israelensis using tapioca peel as the carbon source	IQSR journal of environmental science, Toxicology and food processing	e-ISSN 2319-2402., p-ISSN: 2319-2399, Volume 9, issue II ver I, Nov, 2015, pp 34-37.
5	Process optimization for enhanced biogasproduction from mango pulp waste pp.1772	International Journal of Science and research	ISSN. No. 2318-7964
6	Cost effective production of Penicillin and biogas From rotten oranges by microbial Fermentation technique	International journal Of science And research	2319-7964
7	Preparation,characterization And antibacterial properties of sercin/poly (vinyl alcoho)/ poly(vinyl pyrollidi ne composi tes)	applied polymer
8	Noveltechniques for the cost Effective production of Bacillus thuringiensis Subspecies israelensis	International Journal of mosquito research	ISSN: 2348-3906
9	Cost effective fermentation techniques for the enhanced production of Bacillus thuringiensis subspecies israelensis	International journal of Recent scientific research vol. 10, issue, 02(e) pp 30999- 31005, February, 2019.	0976-3031
10	Enhanced production of Bacillus thuringiensis suspecies Israelensis endotoxin by Supplementation of solubilised bone meal and fish amino acid as medium supplements.	proceedings of conference organized by department of microbiology, SAFI institute of advanced study, Rasiya Nagar, Vazhayoor East P.O, Ramanattukara, Malappuram District -673633,

Paper Presentation:

Papers presented/ Peer rewied and selected for presentation at International/ National Conferences

Sl.No	Title of the Paper Presented	Title of Conference/	Organised by	Whether International/ National
1.	Novel cost effective pre- Treatment protocols to improve biogas production fromagro wastes	ESF-BU- Cebitec conference on microbes and industrial biotechnology,	European Science Foundation	International
2.	Biogas production from pretreated rice straw.	National conference on Recent trends in alternate energy	National institute of technology	National
3	Process optimisation for enhanced biogas production from mango Processing wastes.	The international conference on microbial biotechnology for sustainable development	Punjab university, chandigarh- 160014.	International
4	Presented a paper on the topic novel techniques to improve biogas production from mango processing wastes	The national symposium on emerging trends in biotechnology	Department of biotechnology, Cochin university of science and technology, Kochi.	National
5	Biomethanation of pretreated Rice straw using Pleurotus florida.	RAFTIX, November 6 - 9,2011 at the International Biotechnology conference held at marco island,USA.	Organised by the Society for industrial microbiology(SIM)	International
6	Research work abstract accepted/peer reviewed and invited for paper presentations at the 1-3,December,2011	Microbiotech 11 Braga, Portugal.		International
7	Microbiology and Microbial Technology	Presented research paper at the UGC sponsored national seminar on microbiology and microbial technology	St. Theresas college , Ernakulam	National
8	Waste Management	Delivered a talk for participants of the 14 th refresher course in life sciences conducted by UGC-ASC,University of Calicut,sponsored byUGC	UGC-ASC, University of Calicut, sponsored by UGC	National
9		Biogas 2014		International
10		26 th kerarla science congress		National
11	Procees to improve biogas production from pine apple processing industry wastes.-5	Global biotechnology congress,june 16-19,2014 ,boston ,USA		International
12		National symosium on emerging trends in biotechnology-2014		National
13		6 th world congress on biotechnology,held on Oct.7, 2015		International
14	Bacillus thuringeinsis Based biopesticide Production using pleurotus pretreated rice straw	International conference on biotechnologyfor better Tomorrow (ICBB-2015) held at Pacific ag. research, USA, florida, October 2015,		International
15		Biotechnology world congress, 15-18, Feb, 2016, Dubai,UAE		International
16		International conference on Biotechnology an health care	Biohe-2017	International
17		Euro Biotechnology 2017.	Euro Biotechnol Ogy conference series	International
18	Poultry hydrolysate production by soil microbial consortia for the cost effective production of Bacillus thurigiensus Subspecies israelensis	Global Biotechnology congress, 2017, Boston, USA.	Ureka conference INC	International
19	High rate poultry feather hydrolysate production by aspergillus niger using sold state fermentation technique for the cost effective production Bacillus thuringeinsis subspecies israelensis	World congress on Biotechnology and biological sciences (WCBBS), November 11, 2017 at New Delhi, India.	Conference Era	International
20	Enhanced production of Bacillus thuringiensus Subspecies israelensis delta endotoxin by supplementation of rotten grape juice and fish amino acid as medium suppliments	4 th international congress and expo onbiotechnology and genetic engineering held during September 24- 25, 2018 at Madrid, Spain.	Scientific federation	International
21	Enhanced production of Bacillus thuringiensis Subspecies isralensis delta endotoxin by supplementation of rotten mango and fish amino acid as mediumsupplements	3 rd International Conference Bioscience and biotechnology,2018, 08-09,March, 2018, Colombo, Sri Lanka.	TIIKM	International
22	Enhanced production of Bacillus thuringiensis Subspecies isralenis delta endotoxin by supplementation grape juice and fish amno acid as medium supplements	Research work accepted and invited for Paper presentation at the 2 nd world congress on biotechnology and bioengineering,Dubai, June,25-27, 2018.	Biocore conferences	International
23	cost effectiveproduction of penicillin and biogas from rotten grapes and poultry feathers by fed- batch fermentation technique.	Research work accepted for presentation at the 22 nd edition of int.national conference in biotechnology,16-17, 2018, Amsterdam, Netherlands 30th,Jan,2018.		International
24	Production of Bacillus Thuringiensis subspecies israelensis delta endotoxin by the use of rotten pomegranate and fish amino acid based medium and calcium chloride as medium supplements	Oral presentation on the topic over at the 3 rd advanced biotechnology, May 22-23, 2019, at Rome,Italy.		International
25	Production of Bacillus Thuringiensis subspecies israelensis delta endotoxin by the use of rotten pomegranate and fish amino acid based medium and calcium chloride as medium supplements	Oral presentation on the topic over at the 3 rd world congress on Advanced biotechnology, October 14-15,2019, Rome, Italy.		International

Invited Lectures

Sl no	Title of Lecture/Academic Session	Title of Conference/Seminar etc.	Organised by	International/ National
1	Chaired session II of held on 08 09 ,august ,2012 at EMS seminar complex, university of calicut.	National seminar cum workshop for developing e-contents in bioinformatics,	University of Calicut.	National
2	A practical session on biogas technology	DBT sponsored short term training course (STTC)	DBT	National
3	Infrastructural development opppurtunities in malabar area	Panel discussion	Organised by the kerala chamber of commerce and industry.	National
4	Waste to wealth- possibilities and limitations	National seminar on biotechnology and information technology	Govt. Victoria college, Palakkad.	National
5	Role of industrial biotechnology in waste management	Invited talk	EMEA college of arts and science.	Regional
6	Presented a paper on the role of biotechnology on day to day life	Invited talk	GHSS , Kunnakkavu,	Regional
7	Waste management	Inveted Talk	M.E.S.College Marampally	Regional
8	Invited and delivered a one hour talk on biomethanation of agrowastes ; scale up oppurtunities onn 22 nd august 2014 at the department of microbiology ,st.marys college , thrissur for the UGC sponsored two day national seminar on microbes and green environment.	15 th refresher course in life sciences	UGC-ASC University of Calicut	National
9	Biomethanaion scale up possibilities,	Hands on training for biogas production from domestic waste	Departmentof Life sciences,University of Calicut	National
10	Solid waste management	UGC National Seminar on emerging facets of Biological sciences	Departmentof Zoology,Sree Neela Kanda Govt Sanskrit College, Pattambi, on 15-16,2015.	National
11	Potential of India for the production of biofules,	Inauguration Of microbiology	Majlis arts and science College, Puramannur	Regional
12	Biomethenation- scale up possibilities and conducted practicals for hands on training for biogas production from domestic wastes.	Hands on training for biogas Production from Domestic wastes, sponsored by KSCSTE, govt. of Kerala, 19- 21 st , October, 2015	Organised by the Department of life sciences,university of Calicut with IRTC, Mundoor, Palakkad	National
13	Pollution control activities in dairy sector	Susthira 2030	Organised By department Of psychology, University of Calicut	National
14	Biomethanation- scale up strategies	to the participants of UGCsponsored 9 th refresher course in environmental science and geosciences	Conducted by the UGC HRDC, University of Calicut from 9/11/2016 to 29.11.2016	National
15	Industrial biotechnology scale up and economic aspects on 16.02.2016		EMEA college of arts and science, Kondotty, Kumminiparamaba, Malappuram	Regional
16	Invited as a speaker for the 2 nd world biotechnolgy congress, sao paulo, december, 4-5, 2017			International
17	Solid state fermentation technology	Two day national seminar on- symbiosis 18- Research in agricultural, environmental, industrial and food microbiology:Advances and challenges, March 15-16, 2018	Dept of microbiology, SAFI institute ofadvenced study, Vazhayoor, Ramanattukara,Malappuram, Kerala, Co-sponsored by the Kerala State Council for science technology and environment, govt of Kerala.	National
18	Lecture on Biogas technology	SWASTHA SHUDHI - Science popularization programme onsolid waste management	Organized bythe department Of biotechnology and supported and sponsored by KSCSTE on16.11.2018.	National
19	Why patents/intellectual property be included in the curriculum	Refresher course on Curriculum design development and assessment	MHRD- TLC, department of education,University of Calicut	National
20	Culture of waste management	conduct of extension lecture series	Department of life long Learning and extension, University of Calicut 3 rd February, 2021	National

manish sir

Dr. P .R. Manish Kumar

Professor
Formerly, Co-ordinator & Head of the Department from 2008-10 ; 2012-14 & 2016 - 18.
Dept. of Biotechnology
University of Calicut

Awarded JRF by C.S.I.R. (Govt. of India) ; Awarded Ph.D. in 1991 [ University of Calicut ]; Awarded(Govt. of India) -Biotechnology Research Associateship (1992-’94) at Indian Institute of Science, Bangalore

Lecturer in College then affiliated to Univ. of Calicut – 1994-’96 , joined Dept. of Biotechnology University of Calicut as teaching faculty in 1996;Teaching courses in Cell & Developmental Biology Biology, Molecular Biology and Recombinant DNA Technology – M.Sc. Biotechnology Program ( Govt. of India – DBT sponsored National Program); M.Phil. and Ph.D. Program, University of Calicut; Guiding students under M.Phil and Ph.D.

Undergone Specialized Training in Electron Microscopy ( AIIMS, N. Delhi);Radiotracer techniques (BARC, Mumbai);Basic molecular biology and recombinant DNA techniques ( Univ. of Calicut; IISc Bangalore);Animal cell culture (Reliance Life Sciences, Navi Mumbai);Advances in Biotechnology ( TERI, N.Delhi)

Awarded ‘Best Subject Expert for the year 2000’ by University Grants Commission for the Educational video on DNA Fingerprinting entitled ‘DNA evidence’ produced by Audiovisual Research Centre ( AVRC)

Co- Principal Investigator in DBT ( Govt. of India) sponsored research project (2012-2015) with a total budget of Rs. 47.39 lakhs on ‘Screening for antiproliferative and anticancer drugs from endemic species of Zingiberaceae on human cancer cell lines’.

Membership- academic bodies: Served as Chairman, Board of studies ( Single Board) in Genetics, Member – Board of Studies in Biotechnology, Univ. of Calicut; Served as DBT (Govt. of India) nominee – Institutional Biosafety Committee - External subject Expert nominee– Research Admission Committee – IISR, Calicut;; Department of Biotechnology, VIT, Vellore;Member – Board of Studies ( Marine Biotechnology ) KUFOS –Kerala University of Fisheries and Ocean Studies, Panangad, Kochi.

Coordinator of DBT M.Sc. program and Bioinformatics facility & Head of the Dept - 2008 - 2010 & 2012 – 2014. Coordinator : UGC- ASC / HRDC Refresher courses – Biotechnology (2 courses) and Life Sciences ( 1 course )

Research Interests : Molecular Biology of Cell cycle regulation; DNA cassettes involved in bacterial drug resistance; novel anticancer drugs from plant; human cancer cell lines; DNA damaging agents ;biogenic nanoparticle production and their cellular effects

M.Phil / Ph.D guidance – several awarded as well as ongoing

Publications : ~50 nos ( National and International Journals)
Publications

60.T. Soumya, T. Lakshmipriya, Karel. D. Klika, P. R. Jayasree and P. R. Manish Kumar. Anticancer potential of rhizome extract and a labdane diterpenoid from Curcuma mutabilis plant endemic to Western Ghats of India. Scientific Reports. Nature Publishing Group. Impact factor: 3.998 (Accepted).

59.Ahlam, A.A., Shaniba, V.S., Jayasree, P.R. and Kumar, P.M., 2020. Spondias pinnata (Lf) Kurz Leaf Extract Derived Zinc Oxide Nanoparticles Induce Dual Modes of Apoptotic-Necrotic Death in HCT 116 and K562 Cells. Biological Trace Element Research, pp.1-24.

58.T. Lakmipriya, T. Soumya, P. R. Jayasree and P. R. Manish Kumar. (2019) Cytotoxic and apoptogenic effects of a bioactive fraction isolated from the leaves of a traditional medicinal plant Tridax procumbens. International journal of pharmaceutical sciences and research. November 2019; Vol. 10(11): 5075-5086. E-ISSN: 0975-8232; P-ISSN: 2320-5148. doi:10.13040/IJPSR.0975-8232.10(11).5075-86. Impact factor:0.83

57.Manju Suresh, Nithya N., Vimal K. P. , Jayasree P. R., Manish Kumar P. R. Mutational and phylogenetic analysis of nfxB gene in multidrug-resistant clinical isolates of Pseudomonas aeruginosa hyperexpressing MexCD-OprJ efflux pump. Advances in Microbiology .Scientific Research- an academic publisher. Vol. 9 No.12, December 2019 doi: 10.4236/aim.2019.912064 Impact Factor: 1.22

56.Manju Suresh, Sinosh Skariyachan, Nithya N., Jayasree P. R., Manish Kumar P. R. Mutational variation analysis of oprD porin gene in multidrug resistant clinical isolates of Pseudomonas aeruginosa. Microbial Drug Resistance. Mary Ann Liebert, Inc., publishers. Impact Factor: 2.397 (Accepted)

55 Ahlam Abdul Aziz, V. S. Shaniba, P. R. Jayasree . P. R. Manish Kumar (2019) Physico-chemical, photocatalytic and cytotoxicity evaluation of Annona muricata L. fruit extract derived zinc oxide nanoparticles in comparison to the commercial chemical version. Current Science, 117(9). 1492 – 1504. Impact factor-0.756

54. Book Chapter (accepted) entitled ‘Selective Targeting of Human Colon Cancer HCT 116 Cells by PhytoMediated Silver Nanoparticles’ by V. S. Shaniba, Ahlam Abdul Aziz, Jobish Joseph, P. R. Jayasree, and P. R. Manish Kumar – under Pharmaceutical Science and Technology series – Natural Products Chemistry (Academic Apple Press Inc. USA) – in production – Publn. - May 2020

53. Ahlam Abdul Aziz, Shaniba V.S, Jayasree, P.R. and Manish Kumar P.R.(2019) ' Physico-chemical, photocatalytic and cytotoxicity evaluation ov Annona muricata L.fruit extract derived zinc oxide nanoparticles in comparison to commercial chemical version'. (accepted)

52. Shaniba V.S, Ahlam Abdul Aziz, Jayasree, P.R. and Manish Kumar P.R.(2019) ‘Manilkara zapota(L.) P. Royen leaf extract derived silver nanoparticles induce apoptosis in human colorectal carcinoma cells without affecting human lymphocytes or erythrocytes’. Biological Trace Element Research (Springer Nature) – Published online on Mar 8. 2019; doi: 10.1007/s12011-019-1653-6. [Thomsun & Reuters IF – 2.361]

51. T. Soumya, P. R. Jayasree, M. Deepak & P. R. Manish Kumar (2019) ‘Chemical composition, antioxidant and antiproliferative activities of essential oil from rhizome and leaves of Curcuma mutabilis Škorničk., M. Sabu & Prasanthk., endemic to Western Ghats of India.’ Natural Product Research (Taylor and Francis Group) - https://doi.org/10.1080/14786419.2018.1533826. [Thomsun & Reuters IF – 1.928]

50. Manju Suresh, Nithya N, Jayasree PR, Vimal KP, Manish Kumar PR. (2018). Mutational analyses of regulatory genes, mexR, nalC, nalD and mexZ of mexAB-oprM and mexXY operons, in efflux pump hyperexpressing multidrug-resistant clinical isolates of Pseudomonas aeruginosa. World Journal of Microbiology and Biotechnology. Vol. 34: p. 83 (https://doi.org/10.1007/s11274-018-2465-0 Springer Nature Thomson & Reuters IF - 2.1)

49. Lakshmipriya, T., T. Soumya, P. R. Jayasree, P. R. Manish Kumar. Selective induction of DNA damage, G2 abrogation, and mitochondrial apoptosis by leaf extract of traditional medicinal plant Wrightia arborea in K562 cells. Protoplasma ( Springer Publication) – July 2017 (Doi:10.1007/s00709-017-1137-5) . Thomson & Reuters - Impact factor-2.87

48. Lakshmipriya, T., Soumya, T., Jayasree, P.R. & Kumar P.R.M. Antioxidant, antimicrobial and antiproliferative activities of leaf extracts of the Indian traditional medicinal plant Wrightia arborea. IJPSR. Vol 8,issue 3 March (2017) ISSN 0975-8232.
47. Shaniba, V. S., Aziz A.A. & Kumar, P.R.M. Phyto-mediated synthesis of silver nanoparticles from Annona muricata fruit extract, assessment of their biomedical and photocatalytic potential. IJPSR, Vol 8. Issue 1 (2017) ISSN 0975-8232.
46. Nithya,N, Rabindran, R.,Jayasree, P.R, Faisal, M. & Kumar, P.R.M. Analysis of beta-lactamase,blaNDM-1 phylogeny and plasmid replicons in multidrug-resistant Klebsiella. Indian J. Med. Res. (2017). Vol. 146. S38 – S45. ISSN 0971-5916. Wolters Kluwer Publication Thomson Reuters - Impact factor 2.06
45. Soumya, T., Lakshmipriya, T., Jayasree, P.R. & Kumar, P.R.M. (2016). Evaluation of total phenolics, antioxidant and antiproliferative activities of rhizome extracts from select Zingiberaceae species in South India. Int J. Phyt. Vol 8, issue 3 ISSN 0975-0185.
44. Manju, S., Nithya,N., Jayasree, P.R. & Kumar, P.R.M. (2016). Detection and prevalence of efflux pump-mediated drug-resistance in clinical isolates of multidrug-resistant Gram-negative bacteria from north Kerala, India. Asian J Pharm Clin Res. 9,324-327 ISSN 0974-2441

43. Nithya, N., Manju S., Jayasree P. R&., Kumar, P.R.M. (2016). Detection of blaNDM-1 and genetic relatedness in clinical isolates of Escherichia coli producing Extended spectrum β-lactamase from tertiary care centres in South India. Adv Microbiol. 6,125-132 ISSN 2165-3410

42. Nithya N, Lakshmipriya T, Jayasree PR, Kumar P. R. M. (2015).Drug resistance, Biofilm formation and occurrence of mrkABCDF operon in plasmid- bearing clinical isolates of E.coli and Klebsiella spp. from Kerala,India. Research journal of Pharmaceutical, Biological and Chemical Sciences 6:1044-1049. [ Impact factor: 0.33]

41. Iyyappan Rajan, Jayasree P. R and Kumar P. R. M. (2015). Zerumbone induces mitochondria-mediated apoptosis via increased calcium, generation of reactive oxygen species and upregulation of soluble histone H2AX in K562 chronic myelogenous leukemia cells. Tumor Biol (Published online May 31, (Springer: DOI: 10.1007/s13277-015-3583-z) [ Impact factor: 3.611]

40. Iyyappan Rajan, Remitha Rabindran, Nithya Narayanan, Lakshmipriya T, Jayasree P. R and Kumar P. R. M. (2014). Assesment of cell cycle phase specific effects of zerumbone on mitotically synchronous surface cultures of Physarum polycephalum. Protoplasma (Springer: DOI: 10.1007/s00709-013-0605-9) [ Impact factor: 3.171]

39. Iyyappan Rajan, Remitha Rabindran, Jayasree P. R and Kumar P. R. M. (2014). Antioxidant potential and oxidative DNA damage preventive activity of unexplored endemic species of Curcuma. Indian Journal of Experimental Biology 52:133-138 [Impact factor 1.3]

38. Iyyappan Rajan, Nithya Narayanan, Remitha Rabindran, P. R. Jayasree, P. R. Manish Kumar, (2013). Zingerone Protects Against Stannous Chloride-Induced and Hydrogen Peroxide-Induced Oxidative DNA Damage In Vitro. Biological Trace Element Research ( Springer:155:455–459, DOI 10.1007/S 12011-013-9801-X) [Impact factor 1.6]
37. Rajan Iyappan, Remitha Rabindran, P.R. Jayasree & Kumar P.R.M. (2013) Cell cycle inhibitory effects of leaf extract from Curcuma vamana M. Sabu & Mangaly on mitotically synchronous cultures of Physarum polycephalum Schw. Indian Journal of Experimental Biology 51: 81-87 [ Impact factor 1.3]

36. Remitha Rabindran, Rajan Iyappan, P.R. Jayasree & Kumar P.R.M. (2012). Involvement of 53 kDa protein in wortmannin-mediated abrogation of UV-induced G2 arrest in Physarum polycephalum. International Journal of Integrative Biology Vol.13, 2, p64-70 ISSN (online): 0973-8363,ISSN (print): 0974-2816.

35. Anas K, Jayasree P R, Vijayakumar T, Kumar P. R. M. (2008). In vitro antibacterial activity of Psidium guajava Linn. Leaf extract on clinical isolates of multidrug-resistant Staphylococcus aureus. Indian Journal of Experimental Biology 46: 41 [Impact factor 1.3]

34. Venu T, Vishwandham D, Jayasree P.R and Kumar P.R.M., (2003). Ethanolic extract of Bacopa Monniera (Brahmi) induces shortening of cell cycle durations in naturally synchronous Physarum Polycephalum , Curr. Sci. 85:3, 245. [Impact factor 0.9]

33. Jayasree P.R, Kumar P.R.M. and Nair V.R ,(2000). The plasmodia of Physarum polycephalum an elegant system to demonstrate the importance of genome integrity in traversing the G2/M checkpoint of the cell cycle , Curr. Sci. 78:9 101. [Impact factor 0.9]

32. Kumar P.R.M. and Nair V.R. (1993). Synergistic effect of Griseofulvin and ultraviolet irradiation on mitotic cycle durations in the plasmodia of Physarum polycephalum, Biomedical letters ( Faculty Press, Cambridge, England) 48, 137.

31. Kumar PRM and Nair V.R , (1992). A Comparative study of mitotic delay and inhibition of transcription in cells exposed to UV and heat shock: the possible use of mitotic delay duration as a parameter to assay the extent of damage and recovery , Curr. Sci. 62:3, 314. [Impact factor 0.9]

30. Kumar PRM and Nair V.R , (1991). Synergistic effect of heat-shock and UV irradiation on mitosis and protein synthesis in G2 phase plasmodia of Physarum polycephalum schew-reduction in UV induced mitotic delay in a pre shocked system , Indian J. Exp. Biol. 29, 305. [Impact factor 1.3]

29. Kumar PRM and Nair V.R , (1990). Effect of heat shock on the different phases of the
mitotic cycle in Physarum Polycephalum Curr. Sci. 59:12,615, [Impact factor 0.9]

Conference papers

28.Ahlam Abdul Aziz, Shaniba V.S., Manish Kumar P.R. Antimicrobial and antiproliferative potential of phyto-mediated zinc oxide nanostructures synthesized employing Annona muricata L. CRDB-2019 - International Conference on Research and Development in Biosciences held at Department of Biotechnology and Microbiology, Kannur University on 17-19 January 2019.

27.Soumya T., Lakshmipriya T., Jayasree P.R., Manish Kumar P.R. Phytochemical analysis, antioxidant and antiproliferative activities of organic solvents from Curcuma haritha – an endemic species from Western ghats of Kerala. CRDB-2019 - International Conference on Research and Development in Biosciences held at Department of Biotechnology and Microbiology, Kannur University on 17-19 January 2019 (Best Poster Award).

26.Ahlam Abdul Aziz, Shaniba V.S., Manish Kumar P.R. Genomic level interaction of biogenic zinc oxide nanostructures on prokaryotic and eukaryotic cell systems. Innopharm 3 - 3rd International conference on academic and industrial innovations: Transitions in Pharmaceutical, Medical and BIosciences held at Kala Academy, Goa on 22-23 October 2018 [Second prize]

25.Soumya, T., Jayasree, P.R., Manish Kumar P.R. Phytochemical analysis, antioxidant and antiproliferative activities of organic solvent extracts from Curcuma neilgherrensis leaves. International conference on Phytomedicine (ICPM 2018) held at Bharathiyar University, Coimbatore on 29-31 August 2018.

24. Soumya, T., Jayasree, P.R. & Kumar, P.R.M. ( 2018). Phytochemical analysis, antioxidant and antiproliferative activities of organic solvent extracts from curcuma neilgherrensis leaves. International conference on Phytomedicine. Bharathiyar University. Accepted.

23. Shaniba V.S, Ahlam Abdul Aziz, Dr. P. R Jayasree and Dr. P.R. Manish Kumar. (2018).Green synthesis of silver nanoparticles from Manikara zapota leaf extract and in-vitro evaluation of its biological activities. International conference on emerging trends in agriculture, food processing, engineering and Biotechnology held at Karunya institute of technology & science, Coimbatore, 21-23 February 2018.
22. Shaniba V.S, Ahlam Abdul Aziz, Dr. P. R Jayasree and Dr. P.R. Manish Kumar. (2018) Apoptogenic potential of biosynthesized silver nanoparticles on Human colon cancer HCT116 cell line. 30th Kerala Science Congress, Govt. Brennen College, Thalassery, 28-30 January, 2018.
21. Ahlam Abdul Aziz, V.S. Shaniba, Jayasree P. R. and Dr. P.R. Manish Kumar. (2017). Synthesis, Characterization and in-lab assessment of biofunctionalized zinc oxide nanostructures. International Symposium on nanomaterials for clean energy and health applications, 06-08 December 2017.
20. Shaniba V.S, Ahlam Abdul Aziz, Dr. P. R Jayasree and Dr. P.R. Manish Kumar. (2017). Annona muricata root extract-mediated biomimetic synthesis of silver nanoparticles: Characterization and biomedical applications. 27th Swadeshi Science Congress held at Amrita Viswa Vidyapeetham, Amrita University, Kollam. 07-09 November 2017
19. Manju Suresh , Jayasree P. R. & Manish Kumar P. R. (2017). Contribution of porins and beta-lactamases in carbapenem resistance among multidrug resistant Pseudomonas aeruginosa and their genetic relatedness. 27th Swadeshi Science Congress held at Amrita Viswa Vidyapeetham, Amrita University, Kollam. 07-09 November 2017.
18. Manju Suresh, Jayasree P. R, Manish Kumar P. R. (2017). Prevalence of MexAB-OprM and MexXY efflux systems in multidrug- resistant clinical isolates of Pseudomonas aeruginosa: A threat to environment. Indian Science Congress Association (ISCA) Coimbatore chapter held at Kongunadu arts and science college, Coimbatore. 09-11 October 2017 (Best paper award).
17. Ahlam Abdul Aziz, V.S. Shaniba and P.R. Manish Kumar. (2017). An invitro evaluation of phyto-derived zinc nanoparticles as a promising anti- cancer drug. Indian Science Congress Association (ISCA) Coimbatore chapter held at Kongunadu arts and science college, Coimbatore. 09-11. October 2017 (Best paper award).
16. Lakshmipriya T, Soumya T, Jayasree P.R. & Kumar P.R.M. (2017). Selective killing of human chronic myelogenous leukemic cells by a bioactive fraction isolated from leaves of the Ayurvedic medicinal plant Tridax procumbens. 29th Kerala Science congress, Marthoma College, Thiruvalla, Jan 28 – 30.
15. Soumya T, Tapas Pradhan, Lakshmipriya T, Jayasree P.R. & Kumar P.R.M. (2017). Enhancement of demethoxycurcumin mediated cell death by the checkpoint kinase inhibitor PD 407824 in K562 leukemic cell line – A preliminary report. 29th Kerala Science congress, Marthoma College, Thiruvalla, Jan 28 – 30.
14. Shaniba V.S, Ahlam Abdul Aziz & Kumar, P.R.M. (2017). Green synthesis of silver nanoparticles employing Manikara zapota leaf extract and evaluation of their antioxidant activities. International Conference on Advances in Functional Materials (ICAFM 2017). Anna University, Chennai, 6-8th Jan.
13. Ahlam Abdul Aziz , Shaniba V.S & Kumar, P.R.M. (2017). Pyto-mediated synthesis of photocatalytically active zinc oxide nanoparticles from fresh flowers of Cassia fistuala. International Conference on Advances in Functional Materials (ICAFM 2017). Anna University, Chennai, 6-8th Jan.
12. Soumya, T., Lakshmipriya, T., Jayasree, P.R.& Kumar, P.R.M. ( 2016). Antiproliferative activity of Curcuma mutabilis rhizome extracts against human cancer cell lines. National seminar on drug-discovery and cancer therapy – Dept. of Biochemistry and Molecular Biology, Pondicherry University 25-26 Feb.
11. Manju, Nithya, N., Jayasree, P.R. & Kumar, P.R.M. (2016). Prevalence and rapd analysis of various beta-lactamases- ESBL, ampC and MBL - among multi drug resistant pseudomonas aeruginosa clinical isolates from north Kerala. 28th Kerala Science Congress, University of Calicut, Jan 28-30.
10. Shaniba V.S, Ahlam Abdul Aziz. & Kumar, P.R.M. (2015) Green synthesis and Characterization of siver nano particles from Manikara zapota leaf broth. UGC sponsored National level conference on sustainable Biotechnology,E.M.E.A College of Arts and Science, Kondotti. Dec 16-17.
9. Ahlam Abdul Aziz, Shaniba V.S. & Kumar, P.R.M. (2015) Characterization and in Vitro analysis of Zinc Nanoparticles fabricated using Graviola root extracts. International conference on Nanostructured Polymeric Materials and Polymer Nanocomposites, M.G. University, Kottayam. Nov 13-15.
8. Shaniba, V.S., Aziz A.A. & Kumar, P.R.M. (2015) Biosynthesis of Silver nanoparticles using Annona Muricata fruit extract and assessment of its reducing power, International conference on Nanostructured Polymeric Materials and Polymer Nanocomposites, M.G. University, Kottayam. Nov 13-15.
7. Soumya T., Anju Lata Singh., P.R.Jayasree and P. R. Manish Kumar (2015).Antioxidant and Antiproliferative activities of different organic extracts of Curcuma rakthakanta rhizome and leaf.UGC sponsored National seminar on Recent developments in Cancer Biology, 22-24 July 2015,Organized by Department of Lifesciences,Pazhassiraja College,Pulpally,Wayanad.(First Prize in oral presentation).

6. Ahalam Abdul Aziz, Shaniba V. S., and Manish Kumar P. R. (2014). sol-gel synthesis and characterization of zinc nanoparticles from leaves of Annona muricata. Kerala Science Congress, Allappuzha, Jan 2015.

5. Shaniba V. S., Ahalam Abdul Aziz and Manish Kumar P. R. (2014). Green synthesis of silver nano particles from Annona muricata root extract and its antimicrobial activity. International Conference on Biosciences – State-of-the-art Advancements ( Proceedings of the Society for Education and Scientific Research ), Sept. 11 – 12. Kottayam. P. 76.

4. Lakshmipriya T., Nithya N., Jayasree P. R., and Manish Kumar P. R. (2014). In vitro screening of antimicrobial activity of Wrightia arborea against clinical isolates of multi- drug resistant bacteria. International Conference on Biosciences – State-of-the-art Advancements ( Proceedings of the Society for Education and Scientific Research ), Sept. 11 – 12. Kottayam.. P. 110.

3. Nithya N., Rajan I., Lakshmipriya T., Jayasree P. R., and Manish Kumar P. R. (2014). PCR- based screening to detect the prevalence of Class I integron in meropenem-resistant clinical bacterial isolates – presented in Kerala Science Congress Jan 28-31, Wayanad 2014 (Best Poster Award in Biotechnology)

2. Rajan Iyappan, Remitha Rabindran, P.R. Jayasree & Kumar P.R. M. Antioxidant, DNA protective activity and cellular effects of leaf extracts from Curcuma species (Zingiberaceae) endemic to South India, Paper presented in 6th International Symposium on the family Zingiberaceae, Sept 10 – 13, University of Calicut, Organized by Department of Botany, University of Calicut & Indian Association for Angiosperm Taxonomy(2012)

1. Rajan Iyappan, Remitha Rabindran, P.R. Jayasree & Kumar P.R.M. Paper presented in International Symposium on innovations in Free Radical Research and Experimental Therapeutics &5th Annual Convention of Association of Biotechnology and Pharmacy, Organized by Department of Biotechnology & School of Biotechnology and Health Sciences, Karunya University, Coimbatore December 7-9 (2011).

Accession numbers of DNA sequences deposited in GenBank (NCBI)
1. Manju,S., Nithya,N., Jayasree,P.R. and Manish Kumar,P.R. (2018) Pseudomonas aeruginosa strain Pa6 NalD (nalD) gene, complete cds. GenBank accession no. MG744560.

2. Manju,S., Nithya,N., Jayasree,P.R. and Manish Kumar,P.R. (2018) Pseudomonas aeruginosa strain Pa13 NalD (nalD) gene, complete cds. GenBank accession no. MG757449.

3. Manju,S., Nithya,N., Jayasree,P.R. and Manish Kumar,P.R. (2018) Pseudomonas aeruginosa strain Pa16 NalD (nalD) gene, complete cds. GenBank accession no. MG757450.

4. Manju,S., Nithya,N., Jayasree,P.R. and Manish Kumar,P.R. (2018) Pseudomonas aeruginosa strain Pa6 NalC (nalC) gene, complete cds. GenBank accession no. MG757451.

5. Manju,S., Nithya,N., Jayasree,P.R. and Manish Kumar,P.R. (2018) Pseudomonas aeruginosa strain Pa13 NalC (nalC) gene, complete cds. GenBank accession no. MG757452.

6. Manju,S., Nithya,N., Jayasree,P.R. and Manish Kumar,P.R. (2018) Pseudomonas aeruginosa strain Pa16 NalC (nalC) gene, partial cds. GenBank accession no. MG757453.

7. Manju,S., Nithya,N., Jayasree,P.R. and Manish Kumar,P.R. (2018) Pseudomonas aeruginosa strain Pa6 MexR (mexR) gene, partial cds. GenBank accession no. MG757454.

8. Manju,S., Nithya,N., Jayasree,P.R. and Manish Kumar,P.R. (2018) Pseudomonas aeruginosa strain Pa13 MexR (mexR) gene, partial cds. GenBank accession no. MG757455.

9. Manju,S., Nithya,N., Jayasree,P.R. and Manish Kumar,P.R. (2018) Pseudomonas aeruginosa strain Pa16 MexR (mexR) gene, complete cds. GenBank accession no. MG757456.

10. Manju,S., Nithya,N., Jayasree,P.R. and Manish Kumar,P.R. (2018) Pseudomonas aeruginosa strain Pa5 MexZ (mexZ) gene, complete cds. GenBank accession no. MG757457.

11. Manju,S., Nithya,N., Jayasree,P.R. and Manish Kumar,P.R. (2018) Pseudomonas aeruginosa strain Pa25 MexZ (mexZ) gene, complete cds. GenBank accession no. MG757458.

12. Manju,S., Nithya,N., Jayasree,P.R. and Manish Kumar,P.R. (2018) Pseudomonas aeruginosa strain Pa29 MexZ (mexZ) gene, partial cds. GenBank accession no. MG757459.

13. Manju,S., Nithya,N., Jayasree,P.R. and Manish Kumar,P.R. (2018) Pseudomonas aeruginosa strain Pa16 MexZ (mexZ) gene, partial cds. GenBank accession no. MG757460.

14. Manju,S., Nithya,N., Jayasree,P.R. and Manish Kumar,P.R. (2018) Pseudomonas aeruginosa strain Pa13 MexZ (mexZ) gene, partial cds. GenBank accession no. MG757461.

15- 42. The oprD gene sequences of MDR P. aeruginosa : MH122946-MH122954, MH135303-MH135311, MH142581-MH142588 (26 nos.)

43 – 45. The nfxB gene sequences of MDR P. aeruginosa : MH346508 - MH346510 (3 nos.)
46 - 71. The mexT gene sequences of MDR P. aeruginosa : MH397275-MH397298 (24 nos.)

72. Nithya,N., Remitha,R., Manju,S., Jayasree,P.R., Kumar,P.R.M. Escherichia coli strain EGE14 class 1 integron, partial sequence, Gen Bank: ACCESSION KU751767.

73. Nithya,N., Remitha,R., Manju,S., Jayasree,P.R., Kumar,P.R.M Escherichia coli strain EGE20 class 1 integron, partial sequence, Gen Bank :ACCESSION KU751768.

73. Nithya,N., Remitha,R., Manju,S., Jayasree,P.R., Kumar,P.R.M .Klebsiella sp. EGE5 class 1 integron, partial sequence, Gen Bank : ACCESSION KU751769.

74. Nithya,N., Remitha,R., Manju,S., Jayasree,P.R., Kumar,P.R.M Escherichia coli strain EGE25 class 1 integron, partial sequence,Gen Bank : ACCESSION KU751770.

75. Nithya,N., Remitha,R., Manju,S., Jayasree,P.R., Kumar,P.R.M. Escherichia coli strain EGE26 class 1 integron, partial sequence, Gen Bank : ACCESSION KU751771.

76. Nithya,N., Remitha,R., Jayasree,P.R., Kumar,P.R.M. Klebsiella sp. K27 New Delhi metallo-beta-lactamase (blaNDM) gene, partial cds, Gen Bank: ACCESSION KX090027.

77. Nithya,N., Remitha,R., Jayasree,P.R., Kumar,P.R.M. Klebsiella sp. K28 New Delhi metallo-beta-lactamase (blaNDM) gene, partial cds, Gen Bank : ACCESSION KX090028.

78. Nithya,N., Remitha,R., Jayasree,P.R., Kumar,P.R.M. Klebsiella sp. K1 New Delhi metallo-beta-lactamase (blaNDM) gene, partial cds, Gen Bank : ACCESSION KX090029.

79. Nithya,N., Remitha,R., Jayasree,P.R., Kumar,P.R.M. Klebsiella sp. K13 New Delhi metallo-beta-lactamase (blaNDM) gene, partial cds,Gen Bank : ACCESSION KX090030.

80. Nithya,N.,Manju, S., Jayasree,P.R., Kumar,P.R.M. Escherichia coli strain E7 New Delhi metallo-beta-lactamase (blaNDM) gene, blaNDM-1 allele, partial cds, Gen Bank: ACCESSION KX100581.

81. Nithya,N.,Manju, S., Jayasree,P.R., Kumar,P.R.M Escherichia coli strain E8 New Delhi metallo-beta-lactamase (blaNDM) gene, partial cds, Gen Bank : ACCESSION KX100582.

82. Nithya,N.,Manju, S., Jayasree,P.R., Kumar,P.R.M Escherichia coli strain E10 New Delhi metallo-beta-lactamase (blaNDM) gene, partial cds, Gen Bank : ACCESSION KX100583.

83. Nithya,N.,Manju, S., Jayasree,P.R., Kumar,P.R.M. Escherichia coli strain E23 New Delhi metallo-beta-lactamase (blaNDM) gene, partial cds, Gen Bank : ACCESSION KX100584.

84.Manishkumar.P.R, Manish.J.P.R & Rabindran.R.M. (2008). Physarum polycephalum sequence new. GenBank, EU 371923.
_________________________

Name : Prof. ELYAS K. K.

Present Address : Professor, Head and Coordinator

Dept of Biotechnology

(Address for communication) Calicut University

Kerala, India Pin 673 632

E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

Academic Qualifications :

Ph.D (Immunology) Medical College Trichur 2007

Thesis: Isolation and characterization of Tumour Associated Antigen and their

importance in host immune responses.

M.Tech (Biotechnology) First class with Distinction Anna University Madras 1991
M. Sc.(Biotechnology) First class Aligarh Muslim University UP 1989

Teaching and research Experiences

Presently Working as Professor, Department of Biotechnology, Calicut University from 20^th March 2009 onwards
Worked as Director School Of Health Sciences, Calicut University for Two years.
Appointed as lecturer in Biotechnology, on a regular appointment, in the Department of Biotechnology, Cochin University of Science and Technology, Cochin 682016, Kerala, from 9^th July 1999 to 19^th March 2009.
Appointed as Lecturer in Biotechnology on regular appointment in the School of Biosciences, Mahatma Gandhi University, Kottayam, Kerala, from 27-3-98 to 8-7-99.

Total of 21 years of postgraduate teaching and research

PhD. Guidance

Thesis Awarded/ Submitted under the Guidance

Sl. No.	Title of the thesis	Year, University, And Status
1	Biological activities of heamagglutinins isolated from Chrysolphyllum cainito L. and Leucaena leucocephala (Lam) de Wit and their cytotoxic and antibacterial activities	2019, Calicut University Awarded
2	Isolation and charectarization of endophytic fungui from Elaeocarpus spharucis (Gaertn.) K. Shum. And Quassia indica (Gaertn.) Nooteb. For the production of secondary metabolites.	2019, Calicut University Awarded
3	Therapeutic potential of medicinal plant Thespesia populna (L.) Soland ex Correa with special emphasis towards its antiproliferative activity against cancer cell lines	2018, Calicut University Awarded
4	Purification, biochemical characterization and applications of serine protease inhibitors from Albizia procera (Roxb.) Bent. And Macrotyloma uniflorum (Lam.) Verde.	2018, Calicut University Awarded
5	Purification and characterization of antibacterial peptide MFAP9 with therapeutic potential from Aspergillus fumigatus BTMF9 isolated from marine sediment	2015, Cochin University of Science and Technology Awarded
6	Isolation, Purification, Characterization And Application Of Proteinaceous Protease Inhibitor From Marine Bacterium Pseudomonas Mendocina Btmw 301	2013, Cochin University of Science and Technology Awarded
7	Studies on physicochemical and biological properties of protease inhibitor from edible mushroom Pleurotus floridanus	2012, Cochin University of Science and Technology Awarded
8	Studies on Physicochemical and biological properties of protease inhibitor from edible mushroom Pleurotus floridanus	Cochin University of Science and Technology

PhD thesis work On-going

Sl. No.	Title of the thesis	University
1.
2.	Isolation and characterization of anti-carcinogenic compounds from medicinal plants	Calicut University
3.	A study on the effect of selected plant extracts on prostate cancer and leukemic cancer cell lines	Calicut University
4.	Immuno-Molecular Biological Approach for Characterizing Major Histocompatibility Complex for the Prediction of Rejection and Survival of Kidney Transplants	Calicut University
5.		Calicut University

Papers Published in Journals

Rekha Mol KR, Manzur Ali P, Sapna K, Abraham M, Sarita GB Rafeeq CM, Elyas· K. K.(2022) Production Optimization and In Vitro Evaluation of Anti‑proliferative, Anti‑oxidant and Anti‑ infammatory Potential of the Antibacterial Peptide MFAP9, International Journal of Peptide Research and Therapeutics, 28:139 1-12

Thasneema, K. K., Dipin, T., Thayyil, M. S., Sahu, P. K., Messali, M., Rosalin, T., ... & Hadda, T. B. (2021). Removal of toxic heavy metals, phenolic compounds and textile dyes from industrial waste water using phosphonium based ionic liquids. Journal of Molecular Liquids, 323, 114645.

Madayi, D., Surya, P. H., & Elyas, K. K. (2020). A Glucose binding lectin from Leucaena leucocephala seeds and its mitogenic activity against human lymphocytes. International Journal of Biological Macromolecules, 163, 431-441.

Thasneema, K. K., Thayyil, M. S., Rosalin, T., Elyas, K. K., Dipin, T., Sahu, P. K., ... & Hadda, T. B. (2020). Thermal and spectroscopic investigations on three phosphonium based ionic liquids for industrial and biological applications. Journal of Molecular Liquids, 307, 112960.

Prasad, A. R., Basheer, S. M., Gupta, I. R., Elyas, K. K., & Joseph, A. (2020). Investigation on bovine serum albumin (BSA) binding efficiency and antibacterial activity of ZnO nanoparticles. Materials Chemistry and Physics, 240, 122115.

Megha KB,. Cheriyamundath, S., Madassery, J., & KK, Elyas. (2018). Preliminary Screening Of Phytochemicals And Antiproliferative And Anti-Inflammatory Properties Of Thespesia Populnea (L.) Soland Leaf Extracts. Asian J Pharm Clin Res, 11(5), 382-386.

Surya P. H., Elyas K. K., Deepti Madayi (2018) Bacterial Agglutination By A Lectin From The Leaves Of The Medicinal Plant, Pimenta Dioica (L.) Merr International Journal of Pharmacy and Pharmaceutical Sciences ISSN- 0975-1491 10 (4) 35-43
Mohan, M., & Elyas, K. K. (2018). Anti-hyperglycemic properties of a purified proteinaceous protease inhibitor from Macrotyloma uniflorum seeds. Current Topics in Medicinal Chemistry, 18(29), 2502-2510.

Mohan, M., Kumari, M., & Elyas, K. K. (2018). Antifungal and Antimicrobial Properties of a Purified Protease Inhibitor from Macrotyloma uniflorum Seeds. Current Topics in Medicinal Chemistry, 18(29), 2491-2501.

Sapna, K., Manzur Ali, P. P., Rekha Mol, K. R., Bhat, S. G., Chandrasekaran, M., & Elyas, K. K. (2017). Isolation, purification and characterization of a pH tolerant and temperature stable proteinaceous protease inhibitor from marine Pseudomonas mendocina. Biotechnology letters, 39(12), 1911-1916.
Reshmi, C. R., Menon, T., Binoy, A., Mishra, N., Elyas, K. K., & Sujith, A. (2017). Poly (L-lactide-co-caprolactone)/collagen electrospun mat: Potential for wound dressing and controlled drug delivery. International Journal of Polymeric Materials and Polymeric Biomaterials, 66(13), 645-657.
Sasidharan, A. T. K., Madassery, J., & Elyas, K. K. (2017). Development of an efficient technology for rapid clonal multiplication of Celastrus paniculatus-Willd, an endangered medicinal plant. Asian Journal of Plant Sciences, 16(4), 184-192.

Sheema Dharmapal P, M. Najla1, E. S. Swetha1, P. S. Udayan and K. K. Elyas, (2017) Callus induction and organogenesis from Tinospora formanii Udayan and Pradeep: A rare endemic plant Tropical Plant Research Vol 4(1): 71–76
Thafsi Rasheed, Abraham Mathew, Meenu Mathew, Rajeev Kumar Sukumarsn, Elyas K.K (2015) Optimisation of process parameters for β-glucosidase production by Byssochlamys fulva in slurry state fermentation. Biotech.Res.J.;Vol 1(1):101-107
Anusha T S, Manju Mohan, Deepti Madayi, Deepthi V C, M V Joseph and K K Elyas (2015) Assessment of genetic fidelity of in vitro propagated clones of Celastrus paniculatus Willd by using RAPD based PCR Amplification IOSR- Journal of Biotechnology and Biochemistry1 (6) 29-32.
Rekha Mol K.R, Manzur Ali P.P, Sapna K, Abraham Mathew, Preethi G.U, Sarita G. Bhat1 and Elyas K.K (2014) Production optimization of an antibacterial peptide MFAP9 from marine Aspergillus fumigatus BTMF9 Current Research in Microbiology and Biotechnology, Vol. 2 (6) 530-535

Manzur Ali P P and Elyas K K (2014) Protease Inhibitors; Sources and Applications, Microbial Bioproducts, 1-29

Sapna K S and Elyas K K (2014) Protease Inhibitors: classification, mechanism of action and purification methods., 111-133

Rekha Mol K R and Elyas K K (2014) Antimicrobial Peptides : Characteristics and Potential Applications.

Rekha Mol K R, Manzur Ali P P, Abraham Mathew, Smitha S, Sapna K, Saritha G Bhat and Elyas K K (2011) Screening of various biological sources for antibacterial peptides.

P. P. Manzur Ali & K. Sapna & K. R. Rekha Mol & Sarita G Bhat & M. Chandrasekaran & K. K Elyas (2014) Trypsin Inhibitor from Edible Mushroom Pleurotus floridanus Active against Proteases of Microbial Origin, Appl Biochem Biotechnol Vol 173:167-178
Jissa G. Krishna, Ansu Jacob, Philip Kurian, Elyas KK and M. Chandrasekaran (2013) Marine bacterial prodigiosin as dye for rubber latex, polymethyl methacrylate sheets and paper African Journal of Biotechnology Vol 12 (17), 2266-2269
M.Sajimol Augustine, P.P.Manzur Ali, K.Sapna, K.Elyas, S.Jayalekshmi (2013) Size-dependent optical properties of bio-compatible ZnS:Mn nanocrystals and their application in the immobilisation of trypsin Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy Vol 108, 223-228
Sapna K, Manzur Ali P. P, Abraham Mathew, Rekha Mol K. R, Sarita G. Bhat, Chandrasekaran M and Elyas K. K (2012) Marine Pseudomonas mendocina BTMW 301 as a potential source for Extracellular Proteinaceous Protease Inhibitor. Advanced Bio Tech 11(12):12-15
B. Bijina, Sreeja Chellappan, Jissa G. Krishna, Soorej M. Basheer, K.K. Elyas, Ali H. Bahkali, M. Chandrasekaran (2011) Protease inhibitor from Moringa oleifera with potential for use as therapeutic drug and as seafood preservative, Saudi Journal of Biological Sciences, Vol 18, 273–281
Soorej M. Basheer, Sreeja Chellappan, P.S. Beena, Rajeev K. Sukumaran, K.K. Elyas and M. Chandrasekaran (2011) Lipase from marine Aspergillus awamori BTMFW032: Production, partial purification and application in oil effluent treatment New Biotechnology Vol 28 (6)
B. Bijina, Sreeja Chellappan, Soorej M. Basheer, K.K. Elyas, Ali H. Bahkali, M. Chandrasekaran (2011) Protease inhibitor from Moringa oleifera leaves: Isolation, purification, and characterization, Process Biochemistry, Vol 46, 2291-2300
Soorej M Basheer, Sreeja Chellappan, Beena P S, Rajeev K Sukumaran, Elyas K K and M Chandrasekaran (2011). Lipase from marine Aspergillus awamori BTMFW032: Production, partial purification and application in oil effluent treatment. New Biotechnology 28: 627-638 (IF-2.0).
Bijna B, Sreeja Chellappan, Jissa G Krishna, Soorej M Basheer, Elyas K K, Ali H Bahkali and M. Chandrasekaran (2011). Protease inhibitor from Moringa oleifera active against therapeutic proteases. Saudi J. of Biological Sciences 18, 273–281 (IF 0.56).
Bijna B, Sreeja Chellappan, Soorej M Basheer, Elyas K K, Ali H Bahkali and M Chandrasekaran (2011). Protease inhibitor from Moringa oleifera: Isolation, purification and characterization Process Biochemistry 46: 2291-2300 (IF 2.65).
Jissa G. Krishna, Soorej M. Basheer, K.K. Elyas and M. Chandrasekaran (2011). Prodigiosin from Marine Bacterium: Production, Characterization and Application as Dye in Textile Industry. International J. of Biotechnology and Biochemistry, 7(1): 155-191.
Sreeja Chellappan, Jasmin C, Soorej M Basheer, Archana Kishore, Elyas K K, Sarita G Bhat and M Chandrasekaran (2011). Characterization of an extracellular alkaline serine protease from marine Engyodontium album BTMFS10. Journal of Industrial Microbiology and Biotechnology 38:743–752 (IF- 2.42).
Beena, P.S., Soorej, M. Basheer, Elyas, K.K., Sarita G. Bhat, and Chandrasekaran, M. (2010) Acidophilic tannase from marine Aspergillus awamori BTMFW032. Journal of Microbiology and Biotechnology, 20(10): 1403-1414.

Elyas K.K., Mathew A., Sukumaran R.K., Ali P.P., SapnaK., Kumar S. R., Mol K.R (2010) Production optimization and properties of beta glucosidase from a marine fungus Aspergillus –SA 58, N Biotechnol.

C. Jasmin, Sreeja Chellappan, Rajeev K. Sukumaran, K. K. Elyas, Sarita G. Bhat and M. Chandrasekaran, (2010) Molecular cloning and homology modelling of a subtilisin-like serine protease from the marine fungus, Engyodontium album BTMFS10 World Journal of Microbiology and Biotechnology 26, 1269-1279.

Sreeja Chellappan, C. Jasmin, Soorej M. Basheer, K.K. Elyas, Sarita G. Bhat and M. Chandrasekaran (2006). Production, purification and partial characterization of a novel protease from marine Engyodontium album BTMFS10 under solid state fermentation. Process Biochemistry, 41(4): 956-961. (IF 2.65)

Manjusha, S., Sarita G.Bhat, Elyas K.K, and Chandrasekaran, M., (2005). Multiple Antibiotic Resistances of Vibrio Isolates from Coastal and Brackish Water Areas. American Journal of Biochemistry and Biotechnology. 1(4):201-206

Manjusha S., Sarita G.Bhat, Elyas K.K. and M. Chandrasekaran, 2005. Multiple antibiotic resistance of Vibrio isolates from the coastal and brakish water areas. Am.J. Biochem. And Biotechnol. 1(4) 201-205.

K.R.Shanavas, K.K.Elyas and D.M.Vasudevan (1995) Purification and some properties of a lectin from the seeds of Trichosanthese anguina: Biologia plantarum 37(3) : 417-422.

Papers presented in Seminars and Symposiums

Rekha Mol K.R, and Elyas K. K., “Isolation of antibacterial protein from various biological sources. ” in National seminar on“ Emerging Trends in Biopharmaceuticals”, Department Of Chemistry, Microbiology & Biotechnology, St. Mary’s College, Thrissur, August 2011.
C.Beena, K.R. Shanavas K.K.Elyas and D.M.Vasudevan. (1994) Purification and some physico-chemical properties of a lectin from the seeds of Trichosanthes anguina: Proceedings of the 6^th Kerala Science Congress January 1994,
K.R.Shanavas, K.K.Elyas, C.Beena, V.Mani, T.Vijayakumar & D.M.Vasudevan. Presence of Human Papilloma virus antigens and DNA in oral squamous carcinoma: Proceedings of the 6^th Kerala Science Congress January 1994.
K.K.Elyas, K.R. Shanavas, V.Kala, C.Beena, T.Vijayakumar and D.M.Vasudevan. Antibodies to Herpes simpleuses in oral cancer patients. Proceedings of the 6^th Kerala Science Congress January, Thiruvananthapuram: 1994
K.K. Elyas, P.V. Rao, A.E. Raj, K. Jayaraman and C. M. Lakshman. Lipase production by Candida rugosa in a newly formulated medium: Proceedings of the 5^th Kerala Science Congress, Kottayam, Kerala. 1993
KK.Elyas, P.V. Rao, A.E.Raj, K.Jayaraman and C.M.Lakshmanan. Lipase production by Candida rugosa in slurry fermentation : Abstracts of technical papers. Indian Engineering Congress, Madras 1991

Book Chapter Published

Chandrasekaran, M., Soorej M. Basheer, Sreeja Chellappan, Karthikeyan, P. and Elyas K.K. (in press) Food processing industries-an overview. In Valorization of food processing by-products, Ed: Chandrasekaran M. CRC press, Taylor and Francis group. ISBN:9781439848852
K.R.Shanavas, K.K. Elyas, C.Beena, T.Vijayakumar, V.Mani & D.M.Vasudevan. Human Papillomavirus antigen and DNA in human oral cancer tissues: Oral Oncology Vol.IIIA - Proceedings of the 3rs International Congress on oral cancer, Madras:

Posters presented in National Seminars and Symposiums

Rekha Mol K.R, and Elyas K. K., “Screening of various biological sources for antibacterial peptides.” At National symposium on “Emerging Trends in Biotechnology”, Dept.of Biotechnology, CUSAT, Kochi, September 2011.

Rekha Mol K.R, and K. K. Elyas., “Isolation and partial characterization of fungal antibacterial protein.” At Bioconcorrenza- 2010, National symposium, TNAU, Coimbatore.

GenBank Accession

HQ013324. 2011 Infectious flacherie virus isolates Karnataka RNA- dependent RNA polymerase mRNA, partial cds. Rameshkumar,S., Elyas,K.K., Padma,N., Rao,C.G.P., Vijaya Prakash,N.B. and Rajeurs,S.
HQ285882 JAN-2011 Aspergillus fumigatus strain MF 9 18S ribosomal RNA gene, partial sequence; internal transcribed spacer 1, 5.8S ribosomal RNA gene, and internal transcribed spacer 2, complete sequence; and 28Sribosomal RNA gene, partial sequence. Rekha Mol,K.R., Elyas,K.K.,Manzur Ali,P.P., Sapna,K., Abraham,M.and Ramesh Kumar,S.
GQ 337057. 2009 Aspergillus awamori strain BTMFW032 tannase enzyme gene, partial cds. Beena, P. S., Soorej, M. B., Elyas, K. K., Bhat, S. G. and Chandrasekaran, M.
EU239958. 2007 Jissa,G.K., Beena,P.S., Soorej,M.B., Elyas,K.K. and Chandrasekaran,M. Serratia sp. BTWJ8 16S ribosomal RNA gene, partial sequence.
EU179733.1 2007. Bombyx mori clone SBRL2 unknown mRNA. RameshKumar,S., RajeUrs,S. and Elyas,K.K.
EU179734.1 DEC-2007. Bombyx mori clone SBRL3 unknown mRNA. RameshKumar,S., RajeUrs,S. and Elyas,K.K.
EU179732.1 2007. Bombyx mori clone SBRL1 unknown mRNA. RameshKumar,S., RajeUrs,S. and Elyas,K.K.
EU239958 2007 Serratia sp. BTWJ8 16S ribosomal RNA gene, partial sequence. Jissa,G.K., Beena,P.S., Soorej,M.B., Elyas,K.K. and Chandrasekaran,M.

Membership in Scientific bodies

Life Member, Society for Biotechnologists of India (SBTI).

Life Member, Association of Microbiologists of India, (AMI)

Life Member, Society of Clinical Chemists, Kerala

Life Member, Society for Neurochemistry, India

Membership in academic bodies

Chairman, Board of Studies in Biotechnology, Calicut University 2010 onwards
Member, Board of Studies in Microbiology, Calicut University 2010
Chairman Board of Examiners, BSc Microbiology Calicut University 2002 0nwards
Chairman Board of Examiners, BSc Biotechnology Calicut University 2002-2005
Member Board of Examiners, MSc General Biotechnology Calicut University 2004 onwards
Member Board of Examiners, MSc Food Science and Technology Calicut University 2003
Member Board of Examiners, MSc Biotechnology/ Microbiology M.G. University 1999 0nwards
Member Board of Examiners, MSc Biotechnology/ Microbiology Kannur University 2003-onwards
Member Board of Examiners, M.Sc Biotechnology, Cochin university of Science and Technology, 1999 onwards
Member Board of Examiners, LL.M. Biotechnology (Elective) Cochin university of Science and Technology, 2004-2009
Member, Board of studies in Marine Biotechnology, Cochin university of Science and Technology, 2006 onwards

S. No	Title of Project	Funding agency
1.	Circulating Immune complexes in the diagnosis of diseases (Principal Investigator) At Cochin University of Science and Technology, Cochin	University Grants Commission, New Delhi
2.	Molecular cloning & expression of alkaline protease gene from marine fungi (Co-Investigator) At Cochin University of Science and Technology, Cochin	Department of Biotechnology, New Delhi
3.	Marine biotechnology Application center (Co-Investigator) At Cochin University of Science and Technology, Cochin	Department of Biotechnology, New Delhi
4.	Isolation, characterization and application of protease inhibitors from marine microorganisms At Cochin University of Science and Technology, Cochin	Department of Biotechnology, New Delhi
5	“Screening, Isolation, Purification Characterization of Proteinaceus Protease Inhibitor from Edible and Medicinal plants and its use in therapeutic and Food preservation applications”,	Kerala Biotechnology Commission Kerala State Council for Science, Technology and Environment,