DEPARTMENT OF BIOTECHNOLOGY

Name                                       :           Prof. ELYAS K. K.

Present Address                      :           Professor, Head and Coordinator

Dept of Biotechnology         

(Address for communication)             Calicut University

                                                            Kerala, India Pin 673 632

                                                            E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

Academic Qualifications        :          

• Ph.D (Immunology)  Medical College Trichur 2007

Thesis: Isolation and characterization of Tumour Associated Antigen and their 

  importance in host immune responses.

• M.Tech (Biotechnology) First class with Distinction Anna University Madras 1991
• M. Sc.(Biotechnology) First class Aligarh Muslim University UP 1989

 

Teaching and research Experiences

1. Presently Working as Professor, Department of Biotechnology, Calicut University from 20^th March 2009 onwards
2. Worked as Director School Of Health Sciences, Calicut University for Two years.
3. Appointed as lecturer in Biotechnology, on a regular appointment, in the Department of Biotechnology, Cochin University of Science and Technology, Cochin 682016, Kerala, from 9^th July 1999 to 19^th March 2009.
4. Appointed as Lecturer in Biotechnology on regular appointment in the School of Biosciences, Mahatma Gandhi University, Kottayam, Kerala, from 27-3-98 to 8-7-99.

• Total of 21 years of postgraduate teaching and research

• PhD. Guidance

Thesis Awarded/ Submitted under the Guidance

Sl. No.	Title of the thesis	Year, University, And Status
1	Biological activities of heamagglutinins isolated from Chrysolphyllum cainito L. and Leucaena leucocephala (Lam) de Wit and their cytotoxic and antibacterial activities	2019, Calicut University Awarded
2	Isolation and charectarization of endophytic fungui from Elaeocarpus spharucis (Gaertn.) K. Shum. And Quassia indica (Gaertn.) Nooteb. For the production of secondary metabolites.	2019, Calicut University Awarded
3	Therapeutic potential of medicinal plant Thespesia populna (L.) Soland ex Correa with special emphasis towards its antiproliferative activity against cancer cell lines	2018, Calicut University Awarded
4	Purification, biochemical characterization and applications of serine protease inhibitors from Albizia procera (Roxb.) Bent. And Macrotyloma uniflorum (Lam.) Verde.	2018, Calicut University Awarded
5	Purification and characterization of antibacterial peptide MFAP9 with therapeutic potential from Aspergillus fumigatus BTMF9 isolated from marine sediment	2015, Cochin University of Science and Technology Awarded
6	Isolation, Purification, Characterization And Application Of Proteinaceous Protease Inhibitor From Marine Bacterium Pseudomonas Mendocina Btmw 301	2013, Cochin University of Science and Technology Awarded
7	Studies on physicochemical and biological properties of protease inhibitor from edible mushroom Pleurotus floridanus	2012, Cochin University of Science and Technology Awarded
8	Studies on Physicochemical and biological properties of protease inhibitor from edible mushroom Pleurotus floridanus	Cochin University of Science and Technology

   

      PhD thesis work On-going

Sl. No.	Title of the thesis	University
1.
2.	Isolation and characterization of anti-carcinogenic compounds from medicinal plants	Calicut University
3.	A study on the effect of selected plant extracts on prostate cancer and leukemic cancer cell lines	Calicut University
4.	Immuno-Molecular Biological Approach for Characterizing Major Histocompatibility Complex for the Prediction of Rejection and Survival of Kidney Transplants	Calicut University
5.		Calicut University

Papers Published in Journals

1. Rekha Mol KR, Manzur Ali P, Sapna K, Abraham M,  Sarita GB Rafeeq CM, Elyas· K. K.(2022) Production Optimization and In Vitro Evaluation of Anti‑proliferative, Anti‑oxidant and  Anti‑ infammatory Potential of the Antibacterial Peptide MFAP9, International Journal of Peptide Research and Therapeutics, 28:139 1-12

2. Thasneema, K. K., Dipin, T., Thayyil, M. S., Sahu, P. K., Messali, M., Rosalin, T., ... & Hadda, T. B. (2021). Removal of toxic heavy metals, phenolic compounds and textile dyes from industrial waste water using phosphonium based ionic liquids. Journal of Molecular Liquids, 323, 114645.

3. Madayi, D., Surya, P. H., & Elyas, K. K. (2020). A Glucose binding lectin from Leucaena leucocephala seeds and its mitogenic activity against human lymphocytes. International Journal of Biological Macromolecules, 163, 431-441.

4. Thasneema, K. K., Thayyil, M. S., Rosalin, T., Elyas, K. K., Dipin, T., Sahu, P. K., ... & Hadda, T. B. (2020). Thermal and spectroscopic investigations on three phosphonium based ionic liquids for industrial and biological applications. Journal of Molecular Liquids, 307, 112960.

5. Prasad, A. R., Basheer, S. M., Gupta, I. R., Elyas, K. K., & Joseph, A. (2020). Investigation on bovine serum albumin (BSA) binding efficiency and antibacterial activity of ZnO nanoparticles. Materials Chemistry and Physics, 240, 122115.

6. Megha KB,. Cheriyamundath, S., Madassery, J., & KK, Elyas. (2018). Preliminary Screening Of Phytochemicals And Antiproliferative And Anti-Inflammatory Properties Of Thespesia Populnea (L.) Soland Leaf Extracts. Asian J Pharm Clin Res, 11(5), 382-386.

7. Surya P. H., Elyas K. K., Deepti Madayi (2018) Bacterial Agglutination By A Lectin From The Leaves Of The Medicinal Plant, Pimenta Dioica (L.) Merr International Journal of Pharmacy and Pharmaceutical Sciences ISSN- 0975-1491 10  (4)  35-43
8. Mohan, M., & Elyas, K. K. (2018). Anti-hyperglycemic properties of a purified proteinaceous protease inhibitor from Macrotyloma uniflorum seeds. Current Topics in Medicinal Chemistry, 18(29), 2502-2510.

9. Mohan, M., Kumari, M., & Elyas, K. K. (2018). Antifungal and Antimicrobial Properties of a Purified Protease Inhibitor from Macrotyloma uniflorum Seeds. Current Topics in Medicinal Chemistry, 18(29), 2491-2501.

10. Sapna, K., Manzur Ali, P. P., Rekha Mol, K. R., Bhat, S. G., Chandrasekaran, M., & Elyas, K. K. (2017). Isolation, purification and characterization of a pH tolerant and temperature stable proteinaceous protease inhibitor from marine Pseudomonas mendocina. Biotechnology letters, 39(12), 1911-1916.
11. Reshmi, C. R., Menon, T., Binoy, A., Mishra, N., Elyas, K. K., & Sujith, A. (2017). Poly (L-lactide-co-caprolactone)/collagen electrospun mat: Potential for wound dressing and controlled drug delivery. International Journal of Polymeric Materials and Polymeric Biomaterials, 66(13), 645-657.
12. Sasidharan, A. T. K., Madassery, J., & Elyas, K. K. (2017). Development of an efficient technology for rapid clonal multiplication of Celastrus paniculatus-Willd, an endangered medicinal plant. Asian Journal of Plant Sciences, 16(4), 184-192.

13. Sheema Dharmapal P, M. Najla1, E. S. Swetha1, P. S. Udayan and K. K. Elyas, (2017) Callus induction and organogenesis from Tinospora formanii Udayan and Pradeep: A rare endemic plant Tropical Plant Research Vol 4(1): 71–76
14. Thafsi Rasheed, Abraham Mathew, Meenu Mathew, Rajeev Kumar Sukumarsn, Elyas K.K (2015) Optimisation of process parameters for β-glucosidase production by Byssochlamys fulva in slurry state fermentation. Biotech.Res.J.;Vol 1(1):101-107
15. Anusha T S, Manju Mohan, Deepti Madayi, Deepthi V C, M V Joseph and K K Elyas (2015) Assessment of genetic fidelity of in vitro propagated clones of Celastrus paniculatus Willd by using RAPD based PCR Amplification IOSR- Journal of Biotechnology and Biochemistry1 (6) 29-32.
16. Rekha Mol K.R, Manzur Ali P.P, Sapna K, Abraham Mathew, Preethi G.U, Sarita G. Bhat1 and Elyas K.K (2014) Production optimization of an antibacterial peptide MFAP9 from marine Aspergillus fumigatus BTMF9 Current Research in Microbiology and Biotechnology, Vol. 2 (6) 530-535

17. Manzur Ali P P and Elyas K K (2014) Protease Inhibitors; Sources and Applications, Microbial Bioproducts, 1-29

18. Sapna K S and Elyas K K (2014) Protease Inhibitors: classification, mechanism of action and purification methods., 111-133

19. Rekha Mol K R and Elyas K K (2014) Antimicrobial Peptides : Characteristics and Potential Applications.

20. Rekha Mol K R, Manzur Ali P P, Abraham Mathew, Smitha S, Sapna K, Saritha G Bhat and Elyas K K (2011) Screening of various biological sources for antibacterial peptides.

21. P. P. Manzur Ali & K. Sapna & K. R. Rekha Mol & Sarita G Bhat & M. Chandrasekaran & K. K Elyas (2014) Trypsin Inhibitor from Edible Mushroom Pleurotus floridanus Active against Proteases of Microbial Origin, Appl Biochem Biotechnol Vol 173:167-178
22. Jissa G. Krishna, Ansu Jacob, Philip Kurian, Elyas KK and M. Chandrasekaran (2013) Marine bacterial prodigiosin as dye for rubber latex, polymethyl methacrylate sheets and paper African Journal of Biotechnology Vol 12 (17), 2266-2269
23. M.Sajimol Augustine, P.P.Manzur Ali, K.Sapna, K.Elyas, S.Jayalekshmi (2013) Size-dependent optical properties of bio-compatible ZnS:Mn nanocrystals and their application in the immobilisation of trypsin Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy Vol 108, 223-228
24. Sapna K, Manzur Ali P. P, Abraham Mathew, Rekha Mol K. R, Sarita G. Bhat, Chandrasekaran M and Elyas K. K (2012) Marine Pseudomonas mendocina BTMW 301 as a potential source for Extracellular Proteinaceous Protease Inhibitor. Advanced Bio Tech 11(12):12-15
25. B. Bijina, Sreeja Chellappan, Jissa G. Krishna, Soorej M. Basheer, K.K. Elyas, Ali H. Bahkali, M. Chandrasekaran (2011) Protease inhibitor from Moringa oleifera with potential for use as therapeutic drug and as seafood preservative, Saudi Journal of Biological Sciences, Vol 18, 273–281
26. Soorej M. Basheer, Sreeja Chellappan, P.S. Beena, Rajeev K. Sukumaran, K.K. Elyas and M. Chandrasekaran (2011) Lipase from marine Aspergillus awamori BTMFW032: Production, partial purification and application in oil effluent treatment New Biotechnology Vol 28 (6)
27. B. Bijina, Sreeja Chellappan, Soorej M. Basheer, K.K. Elyas, Ali H. Bahkali, M. Chandrasekaran (2011) Protease inhibitor from Moringa oleifera leaves: Isolation, purification, and characterization, Process Biochemistry, Vol 46, 2291-2300
28. Soorej M Basheer, Sreeja Chellappan, Beena P S, Rajeev K Sukumaran, Elyas K K and M Chandrasekaran (2011). Lipase from marine Aspergillus awamori BTMFW032: Production, partial purification and application in oil effluent treatment. New Biotechnology 28: 627-638 (IF-2.0).
29. Bijna B, Sreeja Chellappan, Jissa G Krishna, Soorej M Basheer, Elyas K K, Ali H Bahkali and M. Chandrasekaran (2011). Protease inhibitor from Moringa oleifera active against therapeutic proteases. Saudi J. of Biological Sciences 18, 273–281 (IF 0.56).
30. Bijna B, Sreeja Chellappan, Soorej M Basheer, Elyas K K, Ali H Bahkali and M Chandrasekaran (2011). Protease inhibitor from Moringa oleifera: Isolation, purification and characterization Process Biochemistry 46: 2291-2300 (IF 2.65).
31. Jissa G. Krishna, Soorej M. Basheer, K.K. Elyas and M. Chandrasekaran (2011). Prodigiosin from Marine Bacterium: Production, Characterization and Application as Dye in Textile Industry. International J. of Biotechnology and Biochemistry, 7(1): 155-191.
32. Sreeja Chellappan, Jasmin C, Soorej M Basheer, Archana Kishore, Elyas K K, Sarita G Bhat and M Chandrasekaran (2011). Characterization of an extracellular alkaline serine protease from marine Engyodontium album BTMFS10. Journal of Industrial Microbiology and Biotechnology 38:743–752 (IF- 2.42).
33. Beena, P.S., Soorej, M. Basheer, Elyas, K.K., Sarita G. Bhat, and Chandrasekaran, M. (2010) Acidophilic tannase from marine Aspergillus awamori BTMFW032. Journal of Microbiology and Biotechnology, 20(10): 1403-1414.

34. Elyas K.K., Mathew A., Sukumaran R.K., Ali P.P., SapnaK., Kumar S. R., Mol K.R (2010) Production optimization and properties of beta glucosidase from a marine fungus Aspergillus –SA 58, N Biotechnol.

35. C. Jasmin, Sreeja Chellappan, Rajeev K. Sukumaran, K. K. Elyas, Sarita G. Bhat and M. Chandrasekaran, (2010) Molecular cloning and homology modelling of a subtilisin-like serine protease from the marine fungus, Engyodontium album BTMFS10 World Journal of Microbiology and Biotechnology 26, 1269-1279.

1. Sreeja Chellappan, C. Jasmin, Soorej M. Basheer, K.K. Elyas, Sarita G. Bhat and M. Chandrasekaran (2006). Production, purification and partial characterization of a novel protease from marine Engyodontium album BTMFS10 under solid state fermentation. Process Biochemistry, 41(4): 956-961. (IF 2.65)

37. Manjusha, S., Sarita G.Bhat, Elyas K.K, and Chandrasekaran, M., (2005). Multiple Antibiotic Resistances of Vibrio Isolates from Coastal and Brackish Water Areas. American Journal of Biochemistry and Biotechnology. 1(4):201-206

1. Manjusha S., Sarita G.Bhat, Elyas K.K. and M. Chandrasekaran, 2005. Multiple antibiotic resistance of Vibrio isolates from the coastal and brakish water areas. Am.J. Biochem. And Biotechnol. 1(4) 201-205.

39. K.R.Shanavas, K.K.Elyas and D.M.Vasudevan (1995) Purification and some properties of a lectin from the seeds of Trichosanthese anguina: Biologia plantarum 37(3) : 417-422.

Papers presented in Seminars and Symposiums

1. Rekha Mol K.R, and Elyas K. K., “Isolation of antibacterial protein from various biological sources. ” in National seminar on“ Emerging Trends in Biopharmaceuticals”, Department Of Chemistry, Microbiology & Biotechnology, St. Mary’s College, Thrissur, August 2011.
2. C.Beena, K.R. Shanavas K.K.Elyas and D.M.Vasudevan. (1994) Purification and some physico-chemical properties of a lectin from the seeds of Trichosanthes anguina: Proceedings of the 6^th Kerala Science Congress January 1994,
3. K.R.Shanavas, K.K.Elyas, C.Beena, V.Mani, T.Vijayakumar & D.M.Vasudevan. Presence of Human Papilloma virus antigens and DNA in oral squamous carcinoma: Proceedings of the 6^th Kerala Science Congress January 1994.  
4. K.K.Elyas, K.R. Shanavas, V.Kala, C.Beena, T.Vijayakumar and D.M.Vasudevan. Antibodies to Herpes simpleuses in oral cancer patients.  Proceedings of the 6^th Kerala Science Congress  January, Thiruvananthapuram: 1994
5. K.K. Elyas, P.V. Rao, A.E. Raj, K. Jayaraman and C. M. Lakshman. Lipase production by Candida rugosa in a newly formulated medium: Proceedings of the 5^th Kerala Science Congress, Kottayam, Kerala. 1993
6. KK.Elyas, P.V. Rao, A.E.Raj, K.Jayaraman and C.M.Lakshmanan. Lipase production by Candida rugosa in slurry fermentation : Abstracts of technical papers. Indian Engineering Congress, Madras 1991

Book Chapter Published

 

1. Chandrasekaran, M., Soorej M. Basheer, Sreeja Chellappan, Karthikeyan, P. and Elyas K.K. (in press) Food processing industries-an overview. In Valorization of food processing by-products, Ed: Chandrasekaran M. CRC press, Taylor and Francis group. ISBN:9781439848852
2. K.R.Shanavas, K.K. Elyas, C.Beena, T.Vijayakumar, V.Mani  & D.M.Vasudevan. Human Papillomavirus antigen and DNA in human oral cancer tissues: Oral Oncology Vol.IIIA - Proceedings of the 3rs International Congress on oral cancer, Madras:

Posters presented in National Seminars and Symposiums

1. Rekha Mol K.R, and Elyas K. K., “Screening of various biological sources for antibacterial peptides.” At National symposium on “Emerging Trends in Biotechnology”, Dept.of Biotechnology, CUSAT, Kochi, September 2011.

2. Rekha Mol K.R, and K. K. Elyas., “Isolation and partial characterization of fungal antibacterial protein.” At Bioconcorrenza- 2010, National symposium, TNAU, Coimbatore.

GenBank Accession

• HQ013324. 2011 Infectious flacherie virus isolates Karnataka RNA- dependent RNA polymerase mRNA, partial cds. Rameshkumar,S., Elyas,K.K., Padma,N., Rao,C.G.P., Vijaya Prakash,N.B. and Rajeurs,S.
• HQ285882 JAN-2011 Aspergillus fumigatus strain MF 9 18S ribosomal RNA gene, partial sequence; internal transcribed spacer 1, 5.8S ribosomal RNA gene, and internal transcribed spacer 2, complete sequence; and 28Sribosomal RNA gene, partial sequence. Rekha Mol,K.R., Elyas,K.K.,Manzur Ali,P.P., Sapna,K., Abraham,M.and Ramesh Kumar,S.
• GQ 337057. 2009 Aspergillus awamori strain BTMFW032 tannase enzyme gene, partial cds. Beena, P. S., Soorej, M. B., Elyas, K. K., Bhat, S. G. and Chandrasekaran, M.
• EU239958. 2007 Jissa,G.K., Beena,P.S., Soorej,M.B., Elyas,K.K. and Chandrasekaran,M. Serratia sp. BTWJ8 16S ribosomal RNA gene, partial sequence.
• EU179733.1 2007. Bombyx mori clone SBRL2 unknown mRNA. RameshKumar,S., RajeUrs,S. and Elyas,K.K.
• EU179734.1 DEC-2007. Bombyx mori clone SBRL3 unknown mRNA. RameshKumar,S., RajeUrs,S. and Elyas,K.K.
• EU179732.1 2007. Bombyx mori clone SBRL1 unknown mRNA. RameshKumar,S., RajeUrs,S. and Elyas,K.K.
• EU239958 2007 Serratia sp. BTWJ8 16S ribosomal RNA gene, partial sequence. Jissa,G.K., Beena,P.S., Soorej,M.B., Elyas,K.K. and Chandrasekaran,M.

Membership in Scientific bodies

       Life Member, Society for Biotechnologists of India (SBTI).

       Life Member, Association of Microbiologists of India, (AMI)

       Life Member, Society of Clinical Chemists, Kerala

       Life Member, Society for Neurochemistry, India

 

Membership in academic bodies

• Chairman, Board of Studies in Biotechnology, Calicut University 2010 onwards
• Member, Board of Studies in Microbiology, Calicut University 2010
• Chairman Board of Examiners, BSc Microbiology Calicut University 2002 0nwards
• Chairman Board of Examiners, BSc Biotechnology Calicut University 2002-2005
• Member Board of Examiners, MSc General Biotechnology Calicut University 2004 onwards
• Member Board of Examiners, MSc Food Science and Technology Calicut University 2003
• Member Board of Examiners, MSc Biotechnology/ Microbiology M.G. University 1999 0nwards
• Member Board of Examiners, MSc Biotechnology/ Microbiology Kannur University 2003-onwards
• Member Board of Examiners, M.Sc Biotechnology, Cochin university of Science and Technology, 1999 onwards
• Member Board of Examiners, LL.M. Biotechnology (Elective) Cochin university of Science and Technology, 2004-2009
• Member, Board of studies in Marine Biotechnology, Cochin university of Science and Technology, 2006 onwards

S. No	Title of Project	Funding agency
1.	Circulating Immune complexes  in the diagnosis of diseases (Principal Investigator) At Cochin University of Science and Technology, Cochin	University Grants Commission, New Delhi
2.	Molecular cloning & expression of alkaline protease gene from marine fungi (Co-Investigator) At Cochin University of Science and Technology, Cochin	Department of Biotechnology, New Delhi
3.	Marine biotechnology Application center (Co-Investigator) At Cochin University of Science and Technology, Cochin	Department of Biotechnology, New Delhi
4.	Isolation, characterization and application of protease inhibitors from marine microorganisms At Cochin University of Science and Technology, Cochin	Department of Biotechnology, New Delhi
5	“Screening, Isolation, Purification Characterization of Proteinaceus Protease Inhibitor from Edible and Medicinal plants and its use in therapeutic and Food preservation applications”,	Kerala Biotechnology Commission Kerala State Council for Science, Technology and Environment,